Words similar to snakebite
Example sentences for: snakebite
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Several pharmacological properties of plants reputed to be snakebite antidotes include antimyotoxic, antihaemorrhagic, analgesic, and antiedematogenic, blockage of cutaneous and intraperitoneal capillary permeability activity caused by the venom and protection from its lethality [ 38 ] . A more direct anti-venom activity would involve complexation of the compounds with venom constituents thus rendering them unable to act on receptors; or to act by competitive blocking of the receptors [ 11 ] . Phenolic compounds especially complex polyphenols like some tannins can bind with proteins [ 42 ] . Alternatively, the catecholamines released as a result of venom-receptor interaction may be antagonised or metabolised more quickly [ 11 ] .
Plant use is embedded in a complex cultural context based on the ancient beliefs of indigenous Amerindians [ 1 ] . Columbian healers also use ethanolic extracts of plants for snakebites, prepare snakebite remedies in the week before Easter and choose plants according to the Doctrine of Signatures [ 139 ] . The cultural basis of the plant use does not mean that the plants have no effect.
marcgraviospsis species for boils and a leaf poultice of Monstera subpinnata for leg pain, as a vesicant and to cauterize wounds [ 15 103 ] . Monstera species accumulate derivatives of caffeic acid [ 102 ] . Monstera pertusa stem fragments were carried in the Antilles as a charm to ward off poisonous snakes, and is applied with cotton to snakebite wounds [ 103 ] .
These compounds may have played a role in the inhibitory effect observed, probably owing to the chelation of the zinc required for the catalytic activity of venom's haemorrhagic metalloproteinases [ 45 ] . Reduction in the intensity of the effects of envenomation could also be achieved by a neutralisation of the venom peptides, polypeptides, proteins and enzymes [ 38 11 ] . There are plants used for snakebite that act by inhibiting the proteolytic activities of the venom and antagonising crotoxin-induced haemolysis, myotoxic and haemorrhagic activities of crotalid venoms [ 46 ] .
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