Words similar to slimb

Example sentences for: slimb

How can you use “slimb” in a sentence? Here are some example sentences to help you improve your vocabulary:

However, we note that slimb mutant cells do not replicate DNA normally and the replication defect is correlated with an increase in E2F in individual cells.
In the absence of heat shock, slimb homozygotes exhibited the early lethality of slimb mutants, but a single 30 minute heat shock at 37°C during first instar was enough to allow some larvae to reach the wandering third instar stage 4 days later.
Interestingly, co-reduction of E2F and slimb function reversed the slimb enhanced mCul1 overexpression phenotype (fig.
For example, a slimb allele shows defects in centrosome duplication control [ 34 ] , and slimb null cells undergo apoptosis [ 35 ] . Both effects could be explained by a failure to inactivate E2F, as E2F promotes centrosome duplication in mammalian cells [ 36 ] and E2F can induce apoptosis [ 12 ] [ 13 ] . A link between Slimb function and the RB/E2F pathway of cell proliferation control is also suggested by the genetic interaction between the C. elegans slimb ortholog lin-23 and the RBF ortholog lin-35 in which lin-35 function limits the severity of the loss of lin-23 [ 37 ] . Since RBF is an important modifier of E2F activity, perhaps this interaction is a reflection of the action of both Lin-23 and Lin-35 on E2F.
These results indicate that elimination of E2F during DNA replication requires Slimb.