Words similar to slimb

Example sentences for: slimb

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Slimb alleles were provided by Tian Xu ( slmb e 4-1) and Bernadette Limbourg-Bouchon ( slmb P 245, slmb 8and slmb 8, hs-slmb ).
For example, a slimb allele shows defects in centrosome duplication control [ 34 ] , and slimb null cells undergo apoptosis [ 35 ] . Both effects could be explained by a failure to inactivate E2F, as E2F promotes centrosome duplication in mammalian cells [ 36 ] and E2F can induce apoptosis [ 12 ] [ 13 ] . A link between Slimb function and the RB/E2F pathway of cell proliferation control is also suggested by the genetic interaction between the C. elegans slimb ortholog lin-23 and the RBF ortholog lin-35 in which lin-35 function limits the severity of the loss of lin-23 [ 37 ] . Since RBF is an important modifier of E2F activity, perhaps this interaction is a reflection of the action of both Lin-23 and Lin-35 on E2F.
Additionally, mutations in slimb that reduced the function of the F-box protein Slimb enhanced the phenotype and led to persistence of E2F in S phase cells.
In the absence of heat shock, slimb homozygotes exhibited the early lethality of slimb mutants, but a single 30 minute heat shock at 37°C during first instar was enough to allow some larvae to reach the wandering third instar stage 4 days later.
Furthermore, we demonstrated that the interaction between Slimb and E2F is dependent on phosphorylation, as expected for the interaction of F-box proteins with their substrates.