Words similar to slimb

Example sentences for: slimb

How can you use “slimb” in a sentence? Here are some example sentences to help you improve your vocabulary:

The starting point for the analysis was an interaction between E2F-1 and Skp2, an F-box protein that is not the mammalian homolog of Slimb.
An hour and a half after a heat shock that restored Slimb expression, BrdU-labelled cells no longer contained detectable levels of E2F (fig.
For example, a slimb allele shows defects in centrosome duplication control [ 34 ] , and slimb null cells undergo apoptosis [ 35 ] . Both effects could be explained by a failure to inactivate E2F, as E2F promotes centrosome duplication in mammalian cells [ 36 ] and E2F can induce apoptosis [ 12 ] [ 13 ] . A link between Slimb function and the RB/E2F pathway of cell proliferation control is also suggested by the genetic interaction between the C. elegans slimb ortholog lin-23 and the RBF ortholog lin-35 in which lin-35 function limits the severity of the loss of lin-23 [ 37 ] . Since RBF is an important modifier of E2F activity, perhaps this interaction is a reflection of the action of both Lin-23 and Lin-35 on E2F.
Note that the severity of this E2F destruction phenotype in comparison to the mild defect in cell cycle programming of E2F destruction upon mCul1 expression is entirely consistent with the fact that the slimb mutant gives a stronger loss of function than the reduction of function imposed by mCul1 overexpression.
To this end, 35S-labelled E2F was produced in vitro in a wheat germ lysate and incubated with the WD repeat region of Slimb fused to GST and bound to beads.