Words similar to sleep-wake
Example sentences for: sleep-wake
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The increase in per expression after the sleep deprivation was specific to the cerebral cortex, although it cannot be ruled out, based on the present study, that circadian gene expression changes with sleep-wake history in specific nuclei within the other two regions examined; i.e., the hypothalamus and basal forebrain.
The sleep-wake distribution in cry1,2 -/-mice was distinct from that of wild type controls (Figure 1) in that sleep variables did not differ between the 12-h light (L) and dark (D) periods (Table 1).
Thus, in both nocturnal and diurnal species, per expression in the cortex is maximal in conjunction with the major waking episode [ 37 49 50 ] . Under conditions where the phase (methamphetamine administration, restricted feeding) or distribution (circadian splitting) of locomotor activity is altered, per expression in the cortex parallels the overt rhythm of wakefulness, whereas the circadian oscillation of per gene expression in the SCN remains unaffected [ 49 51 52 ] . Thus, in contrast to its role in the SCN, PER protein in the cortex is not a component of a self-sustaining circadian oscillator [ 53 ] . Instead, per expression in the cortex seems to the follow sleep-wake history, consistent with the hypothesis that it is related to homeostatic regulation of sleep.
In baseline conditions, wild type mice showed the sleep-wake distribution typical for this nocturnal species with high values of sleep in the light period and low values in the dark period (Figure 1, Table 1).
Changes in sleep drive are thus driven by the sleep-wake history.
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