Words similar to skp
Example sentences for: skp
How can you use “skp” in a sentence? Here are some example sentences to help you improve your vocabulary:
While it may surprise that SKP2 overexpression alone is sufficient to mediate p27 degradation in LNCaP cells, given the known requirement for p27 phosphorylation [ 24 ] , similar observations were made in rat fibroblasts, human U87 cells, and primary rat hepatocytes [ 29 30 31 32 ] . In rat fibroblasts, these findings correlate with SKP2-induced upregulation of cyclin A and CDK2 kinase activity [ 29 32 ] , which could further augment p27 phosphorylation and degradation, ultimately stimulating cells to enter S phase.
In contrast, overexpression of F-box deleted SKP2 did not result in a decline of p27 (Fig.
Overexpression of SKP2 is not sufficient to overcome androgen-mediated G1 arrest
While our study suggests that SKP2 is an important player in p27 regulation in prostate cancer cells, recent studies have also implicated another protein, CSN5/JAB1, in p27 regulation [ 54 55 ] . CSN5 is a subunit of the COP9/signalosome (CSN) complex [ 56 57 58 59 ] , but also forms distinct complexes apparently lacking CSN subunits [ 55 60 61 62 ] . Overexpression of CSN5 in NIH3T3 cells causes p27 export from the nucleus and ectopic degradation [ 54 ] . Notably, like SKP2 [ 33 36 37 38 ] , CSN5 was found to be overexpressed in cancers devoid of p27 [ 63 ] . However, our studies did not reveal any effect of MIB on CSN5 expression.
Although the crystal structure of the SKP1-SKP2 complex, derived from bacterially expressed proteins, revealed a single SKP2 monomer bound to SKP1 [ 28 ] , biochemical studies showed that budding yeast Cdc4p, a close homologue of Pop1p\Pop2p, forms homooligomers when expressed in insect cells (Correll and Deshaies, personal communication).
Loading...