Words similar to skp
Example sentences for: skp
How can you use “skp” in a sentence? Here are some example sentences to help you improve your vocabulary:
As a direct consequence of SKP2 downregulation, p27 is upregulated and cyclin A is downregulated.
SCF: SKP1/Cullin/F-box protein complex
We show that androgen-induced p27 upregulation is paralleled by p27 stabilization and SKP2 downregulation.
While it may surprise that SKP2 overexpression alone is sufficient to mediate p27 degradation in LNCaP cells, given the known requirement for p27 phosphorylation [ 24 ] , similar observations were made in rat fibroblasts, human U87 cells, and primary rat hepatocytes [ 29 30 31 32 ] . In rat fibroblasts, these findings correlate with SKP2-induced upregulation of cyclin A and CDK2 kinase activity [ 29 32 ] , which could further augment p27 phosphorylation and degradation, ultimately stimulating cells to enter S phase.
This may reflect androgen activity in restoring the glandular structure by promoting postmitotic differentiation [ 48 49 ] . Consistent with this view, androgen administration to intact rats resulted in suppression of prostate epithelial cell proliferation and maintenance of morphological gland integrity [ 50 ] . Based on these findings, we propose that the effects of high doses of androgens on SKP2 and p27 in LNCaP cells described here reflect a differentiation and consolidation effect in vitro . If this is the case, LNCaP cells, despite being highly aneuploid derivatives of a metastatic lesion of an advanced cancer [ 39 ] , may have retained some aspects of the normal biphasic mechanism of androgen control observed in castrated rodents.
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