Words similar to skp

Example sentences for: skp

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This finding is in contrast to serum starved rat fibroblasts and human U87 cells arrested in G1 by overexpression of PTEN, in which SKP2 overexpression can drive S phase entry.
Biochemical studies identified SCF SKP2, an E3 that mediates p27 ubiquitylation in vitro [ 20 21 ] . This complex consists of at least four proteins: SKP1, CUL1, HRT1 (=RBX1/ROC1), and SKP2.
Overexpression of SKP2 induces F-box-dependent p27 ubiquitylation
The transient character of these responses may explain the failure to cause efficient S phase entry in the presence of MIB, in particular as co-expression of cyclins was previously shown to synergize with SKP2 in stimulating CDK2 activity and S phase entry [ 30 31 ] . In addition, cyclin A is frequently overexpressed in prostate cancers [ 51 ] . In future experiments, it will be interesting to determine the effect of combined overexpression of SKP2 and cyclin A and cyclin E on cell cycle progression of MIB-arrested cells.
SKP overexpression for 24 or 48 h dramatically increased p27 ubiquitylation activity present in these cell lysates (Fig.