Words similar to skp

Example sentences for: skp

How can you use “skp” in a sentence? Here are some example sentences to help you improve your vocabulary:

As a direct consequence of SKP2 downregulation, p27 is upregulated and cyclin A is downregulated.
Here, we used the androgen-sensitive human prostate cancer cell line LNCaP [ 39 ] as a model system to address the role of SKP2 in androgen-mediated cell cycle control.
The transient character of these responses may explain the failure to cause efficient S phase entry in the presence of MIB, in particular as co-expression of cyclins was previously shown to synergize with SKP2 in stimulating CDK2 activity and S phase entry [ 30 31 ] . In addition, cyclin A is frequently overexpressed in prostate cancers [ 51 ] . In future experiments, it will be interesting to determine the effect of combined overexpression of SKP2 and cyclin A and cyclin E on cell cycle progression of MIB-arrested cells.
Consistent with this idea, biochemical studies based on the crystal structure of the human SKP1-SKP2 complex revealed cooperation of the SKP2 F-box with an adjacent region in binding of SKP1 [ 28 ] . Consistent with this finding, certain truncation mutants of the budding yeast F-box proteins Grr1p and Cdc4p interact poorly with Skp1p, despite the retainment of their F-boxes [ 30 31 ] . On the other hand, the F-box of Pop1p is essential for Rum1p degradation (Fig.
2A), which is carried out by CDK2 in vivo [ 47 ] . Immunoblotting revealed that RB1 suppression in the hypophosphorylated state was efficiently reversed by SKP2 overexpression for 24 or 48 h (Fig.