Words similar to sjögren
Example sentences for: sjögren
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Autoantibodies directed against the Golgi complex were first identified in the serum of a Sjögren's syndrome patient with lymphoma [ 1 ] . Subsequent reports described anti-Golgi complex autoantibodies (AGA) in patients with systemic rheumatic diseases such as systemic lupus erythematosus [ 2 ] , rheumatoid arthritis [ 3 ] , and Wegener's granulomatosis [ 4 ] . Immunoblotting and immunoprecipitation studies have shown that there was heterogeneity of reactivity among AGA [ 5 ] .
Furthermore, in many cases, Sjögren's syndrome diagnosis had been sought because of otherwise unexplained non-exocrine features.
Casciola-Rosen and coworkers have proposed that modifications of autoantigens during cell death, particularly proteolytic cleavage, might be crucial for the generation of autoantibodies in autoimmune diseases [ 23 37 ] . Unique proteolytic fragments of α-fodrin and type 3 muscarinic acetylcholine receptor have been implicated in the generation of autoantibody responses in primary Sjögren's syndrome [ 38 39 ] .
In this group of Sjögren's patients seen at a tertiary care center, abnormal liver function tests were found to be a common non-exocrine feature of 1°SS.
The association of abnormal liver function tests with other non-exocrine features of 1°SS is shown in Figure 2. Patients with abnormal liver function tests were more likely to have lung, kidney or hematological manifestations, when compared to Sjögren's patients without liver disease.