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Example sentences for: sjögren
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The DQA1*0501 allele is strongly associated with early-onset pauciarticular JRA in Northern European populations [ 23 24 ] and with increased risk for juvenile dermatomyositis [ 25 ] and Sjögren's syndrome with high autoantibody production [ 26 27 ] . In our proposed model, aberrant class II MHC regulation could result from altered DEK binding and/or interaction with NF-Y, and aberrant class II expression may alter or enhance reactivity against DEK-derived or other self peptides.
Casciola-Rosen and coworkers have proposed that modifications of autoantigens during cell death, particularly proteolytic cleavage, might be crucial for the generation of autoantibodies in autoimmune diseases [ 23 37 ] . Unique proteolytic fragments of α-fodrin and type 3 muscarinic acetylcholine receptor have been implicated in the generation of autoantibody responses in primary Sjögren's syndrome [ 38 39 ] .
Furthermore, in many cases, Sjögren's syndrome diagnosis had been sought because of otherwise unexplained non-exocrine features.
The association of abnormal liver function tests with other non-exocrine features of 1°SS is shown in Figure 2. Patients with abnormal liver function tests were more likely to have lung, kidney or hematological manifestations, when compared to Sjögren's patients without liver disease.
Autoantibodies directed against the Golgi complex were first identified in the serum of a Sjögren's syndrome patient with lymphoma [ 1 ] . Subsequent reports described anti-Golgi complex autoantibodies (AGA) in patients with systemic rheumatic diseases such as systemic lupus erythematosus [ 2 ] , rheumatoid arthritis [ 3 ] , and Wegener's granulomatosis [ 4 ] . Immunoblotting and immunoprecipitation studies have shown that there was heterogeneity of reactivity among AGA [ 5 ] .
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