Words similar to six-helix

Example sentences for: six-helix

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The following monoclonal antibodies (mAbs) were used: NC-1, a mouse mAb raised against the gp41 six-helix bundle from HIV-1 IIIB [ 20 ] ; and anti-p24 mAb (ImmunoDiagnostics, Inc., Woburn, MA).
The interaction between HIV-1 IIIB, a representative of X4 viruses, and HIV-1 BaL, a representative of R5 viruses, with the micronized form of CAP has the following consequences: 1) elicitation of "dead-end" gp41 six-helix bundles expected to render the virus incompetent to fuse with target cells; 2) loss of virus integrity and stripping off of the envelope glycoproteins; and 3) inactivation of virus infectivity.
Among the two carboxylate polymers (Carbomer 974P and CAP), only soluble CAP (at neutral pH) was able to elicit the formation of gp41 six-helix bundles in both HIV-1 IIIB and BaL and was virucidal against both of these viruses.
Prior engagement of CD4 binding sites is not required for the induction of the six-helix bundles by CAP, but increases their expression (Fig.
Furthermore, interaction with micronized CAP elicited the formation of gp41 six-helix bundles which were undetectable or present at low levels in untreated virus particles [ 37 ] . The six-helix bundles detectable by ELISA were mostly not precipitable by 3% PEG indicating that they were no longer associated with virus particles (Fig.