Words similar to six-helix

Example sentences for: six-helix

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Among the two carboxylate polymers (Carbomer 974P and CAP), only soluble CAP (at neutral pH) was able to elicit the formation of gp41 six-helix bundles in both HIV-1 IIIB and BaL and was virucidal against both of these viruses.
The interaction between HIV-1 IIIB, a representative of X4 viruses, and HIV-1 BaL, a representative of R5 viruses, with the micronized form of CAP has the following consequences: 1) elicitation of "dead-end" gp41 six-helix bundles expected to render the virus incompetent to fuse with target cells; 2) loss of virus integrity and stripping off of the envelope glycoproteins; and 3) inactivation of virus infectivity.
Prior engagement of CD4 binding sites is not required for the induction of the six-helix bundles by CAP, but increases their expression (Fig.
On the other hand, only poly(napthalene sulfonate), in addition to CAP, elicited detectable six-helix bundle formation in HIV-1 BaL.
It was intended to expand these studies to mAb NC-1, specific for the gp41 six-helix bundle [ 20 ] . Results of preliminary studies indicated that CAP did not interfere with the six-helix bundle formation from constituent peptides derived from near the N- and C-terminus of the gp41 ectodomain [ 20 ] ; (own unpublished data).