Words similar to six-helix
Example sentences for: six-helix
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The six-helix bundles were also induced by heating (10 min at 60°C) HIV-1 virus particles (Fig.
Micronized CAP induces gp41 six-helix bundle formation and is virucidal against HIV-1
In summary, the results presented here suggest that treatment of HIV-1 with CAP leads to conformational changes in the envelope glycoproteins, ultimately resulting, in the absence of target cell membranes, in the formation of gp41 six-helix bundles.
Results shown above indicated that HIV-1 adsorbed onto micronized CAP and that the CAP - virus interaction lead to the formation of gp41 six-helix bundles, a hallmark for HIV-1 inactivation.
In order to correlate the properties of CAP in soluble and micronized forms, it was necessary to establish whether or not micronized CAP would bind HIV-1 virus particles and HIV-1 envelope glycoproteins, and induce the formation of gp41 six-helix bundles, a marker of irreversible virus inactivation, as did soluble CAP [ 37 ] . First it was established that HIV-1 gp120 bound to micronized CAP (provided in the form of micronized CAP particles or of a commercial product, "Aquateric", containing about 66% of CAP and used for enteric coating of tablets and capsules in the pharmaceutical industry [ 54 ] ); (Fig.