Example sentences for: single-chain

How can you use “single-chain” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Complex formation of the fibrosarcoma PAI-1, wtPAI-1 or its mutants with single-chain tPA or uPA were performed as described earlier [ 20 ] . Samples of PAI-1s (5 U) were incubated in the absence or in the presence of a 2-fold excess of uPA or tPA in the activity assay buffer.

  • In the experiments described here we introduced amino acid substitutions of A-pocket amino acids in single-chain coat protein heterodimers in order to determine the role of each residue in interaction with A-4 and A-10.

  • The plasmid called p2CTdl-13 contains the WT-WT single-chain homodimer sequence [ 4].

  • However, the introduction of a mutation into one subunit of a single-chain heterodimer causes a defect in only one half-site and therefore inactivates only one of the two RNA-binding sites.

  • Heterodimer complementation relies on the ability to genetically fuse the two subunit of coat protein [ 4], thus producing a single-chain dimer in which the two subunits are covalently linked.


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