Example sentences for: single-chain

How can you use “single-chain” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Heterodimer complementation relies on the ability to genetically fuse the two subunit of coat protein [ 4], thus producing a single-chain dimer in which the two subunits are covalently linked.

  • We previously reported that Thr45 has a remarkable sensitivity to substitution and that fusion of coat protein subunits in the single-chain dimer reverts these and other coat protein structural defects [ 5, 8].

  • Complex formation of the fibrosarcoma PAI-1, wtPAI-1 or its mutants with single-chain tPA or uPA were performed as described earlier [ 20 ] . Samples of PAI-1s (5 U) were incubated in the absence or in the presence of a 2-fold excess of uPA or tPA in the activity assay buffer.

  • For each mutant we constructed four different kinds of single-chain dimers.

  • However, the introduction of a mutation into one subunit of a single-chain heterodimer causes a defect in only one half-site and therefore inactivates only one of the two RNA-binding sites.


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