Words similar to signal-
Example sentences for: signal-
How can you use “signal-” in a sentence? Here are some example sentences to help you improve your vocabulary:
15d-PGJ 2 , 15-deoxy-delta 12, 14-Prostaglandin J 2 ; ERK, Extracellular signal-Regulated Kinase; 4-HNE, 4-hydroxynonenal, MAP kinases, Mitogen-Activated Protein kinases; MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide); PBS, phosphate-buffered saline; PPARs, peroxisome proliferator-activated receptors; RPE, retinal pigment epithelium.
15d-PGJ 2 , 15-deoxy-delta 12, 14-PGJ 2 ; AP-1, activator protein-1; ERK, p42/44, Extracellular signal-Regulated Kinase; LDL, low density lipoprotein; MAP kinases, Mitogen-Activated Protein kinases; MTT (3-(4,5-dimethylthiazole-2yl)-2,5-diphenyltetrazolium bromide); PCD, programmed cell death; PPARs, peroxisome proliferator-activated receptors; SAPK/JNK, Stress-Activated Protein Kinase/ c-Jun NH2-terminal Kinase.
Depending on the experimental conditions, treatment of RPE with H 2 O 2 can cause an alteration of cellular functions [ 6 7 ] or cell death [ 8 9 ] . Cytotoxic levels of H 2 O 2 can cause significant mitochondrial [ 10 ] and genomic [ 11 ] DNA damage in RPE simulating the features of programmed cell death [ 8 12 ] . Studies from other cell types indicate that early cellular events following H 2 O 2 treatment include morphological alterations and actin re-organization [ 13 ] . In addition, activation of the ERK (p42/44, Extracellular signal-Regulated Kinase) MAP kinases (Mitogen-Activated Protein kinases) can occur within minutes following cellular oxidative stress.
The MAP kinase pathway consists of 3 major parallel pathways designated as the ERK (p42/44, Extracellular signal-Regulated Kinase), SAPK/JNK (p46, Stress-Activated Protein Kinase/ c-Jun NH2-terminal Kinase) and p38 pathways [ 12 13 14 ] . Activation of each pathway above involves phosphorylation of a number of upstream and downstream family members of the pathway.
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