Words similar to sigm

Example sentences for: sigm

How can you use “sigm” in a sentence? Here are some example sentences to help you improve your vocabulary:

PH, pleckstrin homology; PI3K, phosphoinositide 3-Kinase; SH2, Src homology-2, SH3, Src homology-3; XLA, X-linked agammaglobulinemia; xid ; x-linked immunodeficiency; TCR, T cell receptor; sIgM, surface immunoglobulin M; (GAP), GTPase-Activating Protein; GST, Glutathione S-Transferase; SDS, Sodium Dodecyl Sulfate; PBS, phosphate buffered saline; NP40, Nonidet P-40; PAGE, polyacrylamide gel electrophoresis.
These results suggest that Rlk can be phosphorylated on Y420 in response to TCR stimulation, supporting a role for Rlk downstream of Src kinases in signaling from the TCR, analogous to Btk's role in signaling from sIgM.
The importance of the Tec kinases in antigen receptor signaling was first demonstrated by the observation that mutations in BTK result in the human disease X-linked agammaglobulinemia (XLA) and the murine counterpart X-linked immunodeficiency ( xid ). These severe B cell immunodeficiencies are characterized by diminished numbers of mature B cells and reduced immunoglobulin levels associated with impaired PLC-γ activation and Ca ++mobilization in response to surface IgM stimulation (sIgM) [ 8, 9, 10, 11].
Btk kinase activity and tyrosine phosphorylation increase upon stimulation of sIgM as well as the IL-5 and IL6 receptors in B cells, and upon crosslinking of the high affinity IgE receptor (FcεRII) in mast cells [ 12, 13, 14, 15].
Src kinases are activated within seconds of sIgM stimulation in B cells, while Btk is activated within minutes [ 14].