Words similar to siah
Example sentences for: siah
How can you use “siah” in a sentence? Here are some example sentences to help you improve your vocabulary:
In addition, the data presented here do not rule out the possibility that Siah may target group I mGluRs to the proteasome should they become damaged, misfolded or should other conditions in the cell warrant mGluR proteolysis.
These data also suggest that Siah1a is acting at the level of the receptor, since much of the calcium current modulation through group I mGluRs proceeds through a Gβγ-mediated pathway similar to that used by α 2 adrenergic receptors and mGluR2 [ 38 40 ] .
Effect of Siah1a on mGluR surface expression and localization
Siah1a has been shown to be a member of the ubiquitin family of proteins involved in protein degradation through the proteasome [ 30 31 33 ] . Therefore, group I mGluR degradation was considered a potential mechanism for the decrease in mGluR-mediated calcium current modulation observed in SCG neurons.
The site of Siah1a interaction is ~50 residues distal to that site [ 36 ] . Although this does not rule out this model, it suggests that it may be less likely than the former model, which implicates CaM as the pivotal interacting protein.