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Example sentences for: siah

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The latter hypothesis predicts a reduction in mGluR cell surface expression or perhaps a change in surface distribution in the presence of Siah1a, such as occurs in the presence of Homer proteins [ 24 44 45 ] . To test whether Siah1a expression altered the surface expression of group I mGluRs, the surface distribution of mGluR5a-myc was examined in the absence and presence of Siah1a.
These proteins have been implicated in many processes including cancer [ 33 ] , apoptosis [ 34 ] and cell cycle regulation [ 35 ] . More recently, an interaction between Siah1a and the C-terminal tail of group I mGluRs was demonstrated [ 36 ] . This interaction was specific for group I mGluRs, as it was not observed in the analogous sequences from group II (mGluR2) or group III (mGluR7) receptors.
However, Siah1a had no detectable effect on mGluR2-mediated calcium current inhibition, consistent with reports demonstrating that Siah1a does not bind to group II mGluRs [ 36 ] . Cells expressing mGluR2 alone exhibited 57 ± 5% inhibition of calcium current in response to glutamate (n = 6), while those coexpressing Siah1a were inhibited 61 ± 2% (n = 6; figure 2).
The GFP-Siah1a-CT construct was made by subcloning the 3' end of Siah1a (from base 228) into pEGFP C1 in frame.
The notion that Siah, a putative ubiquitin ligase, would have other roles in cell signaling is not surprising.