Words similar to siah
Example sentences for: siah
How can you use “siah” in a sentence? Here are some example sentences to help you improve your vocabulary:
Still, it appears likely that Siah1a may play an important role in mGluR signaling in addition to any putative function regarding the proteasome pathway.
This is possible since both Siah1a binding and G protein activation have been attributed to areas on the C-terminus of group I mGluRs [ 36 42 43 ] . Alternatively, Siah1a binding may alter the 'normal' interactions of the receptors with scaffolding proteins or may cause the receptors to be targeted for degradation in the proteasome, effectively reducing the number of receptors that are 'correctly' assembled, or the number of functional receptors at the membrane.
Further, a mutant of Siah1a was constructed with the RING finger domain deleted, such that the protein was unable to act in the ubiquitin/proteasome pathway [ 46 ] . This deletion construct was as effective in attenuating group I mGluR function as the wild type Siah1a, providing supporting evidence that the effect of Siah1a resulted from its physical association with the receptors, rather than through a resulting reduction in receptor expression levels.
These proteins have been implicated in many processes including cancer [ 33 ] , apoptosis [ 34 ] and cell cycle regulation [ 35 ] . More recently, an interaction between Siah1a and the C-terminal tail of group I mGluRs was demonstrated [ 36 ] . This interaction was specific for group I mGluRs, as it was not observed in the analogous sequences from group II (mGluR2) or group III (mGluR7) receptors.
The GFP-Siah1a-CT construct was made by subcloning the 3' end of Siah1a (from base 228) into pEGFP C1 in frame.
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