Example sentences for: shh

How can you use “shh” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Generation of Ptc1 lacZ , Shh and Smo mutant mice has been described previously [ 25 26 ] . Ptc1 lacZ /+mice were kindly provided by Matthew Scott.

  • Having established an in utero assay for Hh signaling, we next investigated whether the agonist could rescue aspects of Shh - or Smo -mutant phenotypes, by monitoring lacZ expression in Smo -/- Ptc1 lacZ /+embryos [ 26 ] and Ptc1 mRNA levels in Shh -/-embryos.

  • Pregnant mice from Shh +/-and Smo +/-intercrosses were treated by oral gavage with vehicle or agonist (15 mg/kg) at 6.5 and 7.5 dpc.

  • At 300 nM, a dose used to induce neuronal development in ES cell cultures [21], Shh produced a significant increase in neurite outgrowth in NS-derived cells (Figure 3D and 3E; see Methods), and resulted in increased Ptc expression (Figure 3F).

  • As expected, Ptc1 expression was not detected in the ventral neural tube of the vehicle-treated Shh -/-embryos (arrowhead, Figure 3g), whereas expression was seen in lateral plate mesoderm and weakly in somites (Figure 3g,k).


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