Words similar to shh
Example sentences for: shh
How can you use “shh” in a sentence? Here are some example sentences to help you improve your vocabulary:
In summary, these studies demonstrate that agonist activity in vivo does not depend upon Shh, but that Smo is absolutely required.
These data are reminiscent of prior studies demonstrating that excess endodermal Shh signaling disrupts pancreas development in vivo [16,34].
At 300 nM, a dose used to induce neuronal development in ES cell cultures [21], Shh produced a significant increase in neurite outgrowth in NS-derived cells (Figure 3D and 3E; see Methods), and resulted in increased Ptc expression (Figure 3F).
The hedgehog ( hh ) gene was identified two decades ago in Drosophila as a critical regulator of cell-fate determination during embryogenesis [ 1 ] . Subsequent work in several model systems has defined and characterized the Hh gene family that encodes highly conserved secreted signaling proteins (for review see [ 2 ] ). Hedgehog (Hh) proteins are synthesized as approximately 45 kDa precursors that autoprocess in an unprecedented fashion, resulting in the covalent attachment of a cholesterol moiety to the amino-terminal half of the precursor [ 2 ] . This processed amino-terminal domain, Hh-Np, is responsible for the activation of a unique and complex signaling cascade that is essential for controlling cell fate throughout development and into adulthood [ 2 ] . In mammals there are three Hh-family proteins: Sonic (Shh), Indian (Ihh), and Desert (Dhh).
The Hh protein used in the studies described here was bacterially overexpressed amino-terminal human Shh modified at its amino-terminal cysteine by an octyl maleimide moiety [ 21 ] . This lipophilic Shh form showed comparable potency to native Shh in the cell-based reporter assay (data not shown).
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