Words similar to shh

Example sentences for: shh

How can you use “shh” in a sentence? Here are some example sentences to help you improve your vocabulary:

In summary, these studies demonstrate that agonist activity in vivo does not depend upon Shh, but that Smo is absolutely required.
Having established an in utero assay for Hh signaling, we next investigated whether the agonist could rescue aspects of Shh - or Smo -mutant phenotypes, by monitoring lacZ expression in Smo -/- Ptc1 lacZ /+embryos [ 26 ] and Ptc1 mRNA levels in Shh -/-embryos.
The midline defects in Shh -/-embryos were at least partly rescued by agonist treatment (compare Figure 3gand 3h; red arrows).
Furthermore, this supports the data showing that the agonist can activate signaling in Shh -/-embryos (Figure 3) and suggests that the agonist function is not only downstream of the Hh protein but also independent of the endogenous Hh-signaling modulators, Tout veloux and HIP, that act via the Hh ligand [ 2 ] . The competition experiment with forskolin showed identical inhibition curves for Hh protein and the agonist, strongly suggesting that the action of the small molecule is upstream of the protein-kinase-A-sensitive step in the pathway.
The Hh protein used in the studies described here was bacterially overexpressed amino-terminal human Shh modified at its amino-terminal cysteine by an octyl maleimide moiety [ 21 ] . This lipophilic Shh form showed comparable potency to native Shh in the cell-based reporter assay (data not shown).