Words similar to shh

Example sentences for: shh

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The Hh protein used in the studies described here was bacterially overexpressed amino-terminal human Shh modified at its amino-terminal cysteine by an octyl maleimide moiety [ 21 ] . This lipophilic Shh form showed comparable potency to native Shh in the cell-based reporter assay (data not shown).
Most notably, the neural-plate explant assay has defined the concentration-dependent role that ventrally expressed Shh plays in opposing dorsally expressed bone morphogenetic proteins (BMPs) to pattern the neural tube [ 2 ] . The assay demonstrates that the Hh-signaling cascade can distinguish between small concentration differences in the Hh ligand to instruct the differentiation of specific neuronal cell types.
In summary, these studies demonstrate that agonist activity in vivo does not depend upon Shh, but that Smo is absolutely required.
Following agonist treatment, we observed that the neural tube and somite expression of Ptc1 in Shh -/-embryos was greater than vehicle-treated wild-type levels (compare Figure 3h,lwith 3e,i).
Shh +/-and Smo +/-mice were kindly provided by Andrew McMahon.