Words similar to shedding

Example sentences for: shedding

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We confirmed our previous observation [16] that atorvastatin produces an increase in sAPP α shedding that is dose-dependent, reaching a maximum effect at 5 μM.
However, the molecular mechanisms by which statins modulate ectodomain shedding remain to be elucidated [17,18].
Cell-associated HS proteoglycans can undergo regulated shedding from the membrane into the soluble extracellular matrix or culturing medium converting the membrane anchored molecules into soluble effectors [ 1 2 ] . In the conditioned media of all the tested batches of retinoblastoma cells, we detected heparin and HS with binding affinity for PEDF.
Taken together, these results suggest the existence of a reciprocal relationship between isoprenoid-mediated Rho/ROCK signaling and sAPP α shedding, i.e., activation of ROCK1 blocks basal and stimulated shedding while ROCK1 inhibition apparently relieves a tonic negative influence exerted on shedding by ROCK1 activity.
Most of this shedding is catalyzed by the α-secretase pathway, but a trace amount (<5% [49]) is catalyzed by β-secretase/β-site APP cleaving enzyme [50].