Words similar to sex-matched
Example sentences for: sex-matched
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In tissues such as the hypothalamus, where we see large differences in gene expression in age- and sex-matched mice of the same strain, this variability may reflect high levels of variability in behavior that are seen in inbred mice raised and tested under seemingly identical laboratory conditions [ 50 ] .
These samples showed a correlation coefficient of 0.782 when all tags were considered or 0.500 when highly abundant tags were excluded, a high value for cumulative p -value differences (Figure 4), and large numbers of tag differences (Figure 5g), suggesting that pronounced variation in gene expression is found even in genetically identical age- and sex-matched individuals housed in similar laboratory environments.
There are, however, several published microarray experiments in which, although individual variation in gene expression was not explicitly addressed, variation in gene expression in age- and sex-matched individual mice or pooled samples of three or fewer mice was measured and found to be relatively small [ 36 37 38 39 ] . These include data from both peripheral tissue and brain that reported r -values for individual mice at around 0.98 [ 37 38 ] , and one publicly available dataset of inter-individual comparisons of CNS tissues [ 38 ] . We analyzed this dataset and found it to have correlation coefficients in the 0.97-0.
Although no studies to our knowledge have addressed the question directly, the limited body of data on expression profiling of age- and sex-matched humans generally reports significant variation in gene expression among individuals [ 25 26 27 ] , although little of these data are publicly available.
MicroSAGE data show pronounced differences in gene expression between age and sex-matched samples
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