Words similar to senescence
Example sentences for: senescence
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As recently indicated [ 30 ] , certain types of placental abnormality have also been ascribed to the villous immaturity (low or no Thy-1 differentiation protein expression in placental villi and a lack of blood sinusoid dilatation - PT4, see above) accompanied by an existing (diabetes mellitus) or absent placental hypertrophy (intrauterine growth retardation) - Table 1. However, it has been suggested that although chronic placental adaptations may be successful for the fetal survival, e.g. in placental senescence or maternal diabetes, they may lead to adverse outcomes later in the life of an individual [ 22 ] . Therefore, although it might not be apparent in the newborn, the abnormal placenta may indicate a burden for the future of an individual and for the quality of the human population.
It is important to mention that our experiments were conducted at similar passage levels (passage 6 to 8) in both groups, since senescence of fibroblasts is associated with a shift from the biosynthesis of PGI 2 to TXA 2 [ 24 25 ] . It is possible that the difference seen in our study between HF-IPF and HF-NL could result from comparing fibroblasts of different ages.
The existence of placental aging is still debated, yet various clinical, morphological, cellular and molecular aspects of placental senescence have been indicated [ 20 21 24 25 27 28 29 30 45 46 47 ] . However, it is still unclear if there are any consequences of placental aging for normal pregnancy, delivery, and neonatal birth weight and Apgar scores [ 29 48 49 ] . It has to be noted that even the abnormal placenta may have the capacity to improve its function and compensate for demands of the growing fetus, e.g., by elongation and excessive dilatation of villous sinusoids [ 26 50 ] .
Though apoptosis in adult muscles has been described, and may result from changes within bcl2/bax system, alteration in pathways that regulate differentiation of muscle cells, changes in the myonuclei, and the nature of pathways inducing senescence of skeletal muscles are still far from being clear [ 14 ] .
The WRKY transcription factors are involved in defense, wounding, senescence and plant development [ 7 16 70 71 72 73 ] . There are 70 genes with a WRKY domain in the Arabidopsis genome and six of them (WRKY15, 25, 33, 46, 62, 70) are in the stress cDNA collection.
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