Example sentences for: self-splicing

How can you use “self-splicing” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The structural and kinetic properties of the Group I self-splicing intron from the thymidylate synthase ( td ) gene in bacteriophage T4 have been extensively studied.

  • However, four of the constructs, Th1P6, Th2P6, Th3P6, and Th1P5, showed good activity (>10% of wild-type) and increased self-splicing in the presence of theophylline.

  • However, the Group I self-splicing intron is a much more complicated ribozyme than either the hammerhead or the L1 ligase; for example, the tertiary structure of the Group I intron is established by a complicated folding pathway.

  • In this regard, it is notable that some natural Group I introns have proven to be highly dependent upon protein cofactors, [ 35 ] and that Group I introns have been engineered whose tertiary structure and activity is dependent upon a peptide [ 36 ] . Such applications could also be melded with other innovations dependent upon the Group I self-splicing intron, such as the introduction of a trans-splicing intron that can potentially repair or modulate the expression of a given mRNA.

  • The T. acidophilum intein retains efficient self-splicing activity when expressed in E. coli.


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