Example sentences for: self-reactive

How can you use “self-reactive” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The most profound form of T-cell tolerance involves deletion of potentially self-reactive T cells during thymic selection.

  • These self-reactive T cells are exquisitely regulated, and their activation can result in autoimmune diseases.

  • There is accumulating evidence that, in addition to activation-induced cell death or anergy, T-cell-mediated dominant control of self-reactive T cells represents one mechanism for maintaining immunological tolerance [ 1 2 3 ] . Studies conducted in a number of experimental models have demonstrated the existence of regulatory T-cell subsets that prevent activation of autoreactive T cells.

  • This extraordinary plasticity has a price: V(D)J recombination can produce self-reactive receptors leading to autoimmune disease [ 38, 39] and may err to create oncogenic chromosomal translocations [ 40].


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