Words similar to seco-steroid

Example sentences for: seco-steroid

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Low intestinal calcium absorption efficiency in humans is common and contributes to negative calcium balance and bone loss [ 1 ] . Recent epidemiological evidence suggests that low fractional calcium absorption is a significant risk factor for future osteoporotic hip fracture [ 2 ] . The primary homeostatic mechanism for altering calcium absorption in response to low dietary calcium intake and increased calcium requirements during growth is an increase in plasma 1,25-dihydroxyvitamin D, the active hormonal form of vitamin D produced in the kidney [ 3 ] . 1,25-dihydroxyvitamin D is a seco-steroid that acts on gene transcription through a nuclear steroid receptor protein and also may have nongenomic actions mediated by a putative plasma membrane vitamin D receptor [ 4 ] . Changes in vitamin D status primarily alter the rate of Ca absorption in the proximal small intestine.