Words similar to scid

Example sentences for: scid

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Purification of CD4 +CD25 +and CD4 +CD25 -T cells and cell transfer in SCID mice
First, CD4 +T cells selectively proliferate in response to proteoglycan antigens [ 14 ] . Second, prevention of arthritis can be achieved by in vivo treatment with anti-CD4 monoclonal antibodies [ 15 ] . Third, arthritis can be transferred to naïve BALB/c or severe combined immunodeficient (SCID) mice using T and B cells from arthritic animals [ 16 17 18 ] . Fourth, a proteoglycan-specific T-cell hybridoma (T-helper-1 type) can induce arthritis in BALB/c mice [ 19 ] . Finally, CD4 +T cells from arthritic animals are resistant to activation-induced cell death [ 20 ] . These data suggest a breakdown of peripheral tolerance and accumulation of autoreactive T cells in the periphery.
The transfers of CD4 +CD25 +T cells did not have any impact on incidence and severity of the disease in SCID mice as compared with transfer of CD4 +CD25 -T cells (Fig.
A total of 5 × 10 5CD4 +CD25 +or CD4 +CD25 -T cells were injected intraperitoneally, along with 1 × 10 7spleen cells from arthritic animals that were depleted of CD25 +cells and 100 μg proteoglycan, into SCID mice.
3a), suggesting that the CD4 +CD25 +regulatory T cells did not protect SCID mice from arthritis.