Example sentences for: scf

How can you use “scf” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Thus, CSN deficiency appears to stimulate Pcu3p-associated ubiquitin ligase activity in vitro . A similar stimulation was obtained for substrate-specific polyubiquitylation of phosphorylated Rum1p by SCF Poppurified from csn5 mutants (unpublished observation).

  • As shown above and in previous genetic work [ 18 20 ] , SCF Pop1p-Pop2p-dependent Rum1p degradation requires two different proteins with highly conserved F-boxes (Fig.

  • Most yeast and animal SCF substrates must be post-translationally modified, usually by phosphorylation, before they are recognized by their cognate F-box protein.

  • The failure of the Pop2p F-box to replace the F-box of Pop1p as well as the finding that it is not essential for Rum1p degradation could be explained, if it was not critically involved in SCF Pop1p-Pop2pprotein interactions.

  • SCF complexes share homologues of the core components cullin 1 (CUL1), SKP1, and the RING domain protein HRT1/RBX1/ROC1, which associate with different F-box proteins and ubiquitin-conjugating enzymes [ 1].


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