Example sentences for: sb-

How can you use “sb-” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Fast TGFβ responder genes, such as smad7 , whose maximum activation by TGFβ was reached after 60 min, was only slightly affected by SB-203580, while slow responders, such as pai-1, pthrp or upa , that showed peak activation after 180-240 min, were very sensitive to the repressive effect of SB-203580.

  • SB-202190 and SB-203580 downregulate transcription from TGFβ-responsive genes

  • We wanted to know to what extent SB-202190 and SB-203580 interfere with TGFβ-dependent Smad3 nuclear import in the invasive MDA-MB-231 breast cancer cell line.

  • The rapid induction of smad7 mRNA was basically unaffected by SB-203580; this could possibly explained by a lower amout of Smad3 necessary to activate the Smad7 promoter.

  • Using SB-203580, we found that not only was the total level of nuclear Smad3 in the presence of TGFβ reduced, but also that the nuclear entry of Smad3 was delayed and less prolonged.


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