Words similar to sarcoma
Example sentences for: sarcoma
How can you use “sarcoma” in a sentence? Here are some example sentences to help you improve your vocabulary:
To test this possibility, NIH 3T3 cells were transiently transfected with a CAT reporter gene driven by one copy of the wild type SRE upstream of the Rous sarcoma virus long terminal repeat minimal promoter.
First, our viral backbone is a modified MoMLV vector that incorporates genetic elements (myeloproliferative sarcoma virus long-terminal repeats and B2 mutation) associated with resistance to transcriptional silencing following proviral integration in primary cells [ 7 8 ] . While we did not perform a detailed comparison of EGFP expression in FLS using the modified and unmodified vector backbones, preliminary experiments suggested that the modified vector was superior (J Yang, unpublished observations).
For example, early investigators observed that transfection of untransformed B cells with a plasmid for constitutive expression of IL-6 conferred the tumorigenic phenotype on the cells [ 2 ] . IL-6 is a key factor in myeloma progression and survival [ 3 4 ] , and also in Kaposi's sarcoma, a solid tumor [ 5 ] . In myeloma, the standard therapy for treatment includes prednisone, which acts by inhibiting IL-6 synthesis.
The pRET2 incorporates long-terminal repeats from the myeloproliferative sarcoma virus [ 7 ] , and a point mutation in the primer binding site [ 8 ] . A vector expressing the human cyclooxygenase-2 (COX-2) cDNA was constructed in the same backbone (pRET2.COX2).
Enhancement of IL-6 production by dexamethasone treatment has been previously observed in Kaposi's sarcoma cells [ 32 ] . In the case of NRP-154 cells, the steroid-responsive element for dexamethasone on the IL-6 promoter may have been mutated to a form that does not bind steroid receptors.
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