Words similar to sapp

Example sentences for: sapp

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Conversely, DN ROCK1 alone activated shedding of sAPP α . Cellular levels of holoAPP were not affected by transfection (Figure 5; p < 0.05 versus GFP control).
Monoclonal antibody 6E10 against residues 1–16 of human Aβ (Signet, Dedham, Massachusetts, United States) was used to detect human holoAPP or sAPP α . Anti-ROCK1 antibody was purchased from Chemicon (Temecula, California, United States).
We therefore tested the effects of FTI-1 on statin-stimulated sAPP α shedding.
Under all circumstances, stimulated sAPP α shedding was completely blocked using TNFα protease inhibitor 2, a standard α-secretase/metalloproteinase inhibitor (Figure 2).
Treatment of cells with a farnesyl transferase inhibitor or expression of a dominant negative (DN) ROCK1 molecule led to enhanced sAPP α shedding, supporting the notion that shedding is modulated by the isoprenoid pathway.