Words similar to sapp

Example sentences for: sapp

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When CA ROCK1 was introduced, however, shedding of sAPP α from both untreated and simvastatin-treated cells was diminished (Figure 5; p < 0.05 versus GFP control).
Sisodia and colleagues [39] demonstrated that arrest of APP endocytosis from the plasma membrane by deletion of its NPXY clathrin-coated vesicle targeting sequence [40,41] can dramatically stimulate sAPP α shedding, presumably by extending the half-life of co-localized α-secretase and APP on the plasma membrane.
HoloAPP levels are likely limiting at one or more sorting steps in the late secretory pathway, since activated sAPP α shedding is apparently accompanied by diminished generation of sAPP β [51].
Secretory maturation toxicity is one possible mechanism for elevated levels of intracellular mature holoAPP and causes retarded conversion of mature holoAPP to sAPP α . This pattern was not observed following statin treatment, excluding maturation toxicity as a mechanism underlying the altered levels of mature cellular holoAPP.
Since csAPP levels were only slightly raised in the same statin-treated cells in which sAPP α shedding was dramatically increased, we interpret this disparity to indicate that the effector of statin-stimulated shedding is probably intrinsic to the plasma membrane.