Example sentences for: sapp

How can you use “sapp” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Unlike sAPP α , which is generated at the plasma membrane, most sAPP β is probably generated by cleavage within the trans -Golgi network and endocytic pathway vesicles.

  • Monoclonal antibody 6E10 against residues 1–16 of human Aβ (Signet, Dedham, Massachusetts, United States) was used to detect human holoAPP or sAPP α . Anti-ROCK1 antibody was purchased from Chemicon (Temecula, California, United States).

  • Based on these reports, we asked whether the Rho/ROCK pathway might play a role in controlling shedding of sAPP α following statin application.

  • Co-treatment of cells with PO plus either atorvastatin or simvastatin caused stimulation of sAPP α shedding to levels greater than the maximal levels of shedding achievable with inhibition of endocytosis using PO alone or with maximal doses of either statin alone ( p < 0.05).

  • Low doses (<1 μM) of mevalonic acid did not affect statin-induced sAPP α shedding, but complete inhibition of statin-activated sAPP α shedding was achieved with higher doses of mevalonic acid (100 μM).


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