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How can you use “sα” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • First, others have shown that in COS-7 cells endogenous i2 is not detected at PM but only found intracellularly [ 3 4 ] , although one cannot rule out that a small but functionally significant fraction of i2 reaches the PM.

  • Thus, it is more likely that indeed i2 is deficient in binding to βγ, but this effect is a consequence of its instability.

  • i2 may exist in a state that does not interact well with βγ simply because it is in the process of being irreversibly inactivated [ 9 10 ] . Similarly, α i2 A327S appears not to be defective in its intrinsic ability to interact βγ [ 10 ] , and co-expression of βγ shifts α i2 A327S, like i2 , from intracellular to plasma membranes (Figure 8).

  • Thus, the following experiments concentrated on addressing the alternative hypothesis: i2 is unstable and rapidly degraded due to disruptions in the C-terminus, and such instability results in a failure of i2 to reach its proper place at the PM.

  • Consistent with this idea, i2 was refractory to stable expression even though cells stably expressing α i2 were easily selected (not shown).


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