Words similar to rtk

Example sentences for: rtk

How can you use “rtk” in a sentence? Here are some example sentences to help you improve your vocabulary:

The down-regulation is most apparent on cellular receptors that have intrinsic receptor tyrosine kinase (RTK) activity and signal transduction members that mediate RTK function; including the Ras-Raf-MEK pathway, and co-activators such as p300/CBP and SRC-1, which mediate gene expression related to hormone receptor genes.
Despite the presence of these catalytic RTK inhibitors, δ-opioid-mediated ERK activation was not significantly altered in comparison to untreated cultures (Figure 9).
It is hypothesized that trans-tyrosine phosphorylation of the EGFR creates protein phosphotyrosine binding sites that act as a surrogate scaffold for ERK activation [ 7 ] . Since ORs share many similarities with LPAR and β 2 -ARs in the way they activate the ERK pathway [ 9 15 ] , we chose to examine whether RTK transactivation occurs and is a necessary aspect of δ-opioid-mediated ERK activation.
, unpublished observations), similar to what we previously reported for the δ-OR expressed in Chinese hamster ovary or HEK-293 cells [ 11 13 ] . Thus, in at least two different cell lines, HEK-293 and C6 glioma, we have significant evidence that transactivation of an endogenously expressed RTK is not required for ERK activation through opioid receptors.
These data suggest that the tyrosine phosphorylation of GPCRs may allow them to signal ERKs in the absence of RTK or FAK phosphorylation by acting as their own scaffolds.