Example sentences for: rtk
How can you use “rtk” in a sentence? Here are some example sentences to help you improve your vocabulary:
Determining whether a co-expressed RTK is structurally necessary for δ-OR-mediated ERK activation
These data suggest that the tyrosine phosphorylation of GPCRs may allow them to signal ERKs in the absence of RTK or FAK phosphorylation by acting as their own scaffolds.
In this report, we have presented considerable evidence that δ-ORs and EGFRs activate ERKs, independently, without the need for transphosphorylation of a co-expressed RTK.
Despite the presence of these catalytic RTK inhibitors, δ-opioid-mediated ERK activation was not significantly altered in comparison to untreated cultures (Figure 9).
It is hypothesized that trans-tyrosine phosphorylation of the EGFR creates protein phosphotyrosine binding sites that act as a surrogate scaffold for ERK activation [ 7 ] . Since ORs share many similarities with LPAR and β 2 -ARs in the way they activate the ERK pathway [ 9 15 ] , we chose to examine whether RTK transactivation occurs and is a necessary aspect of δ-opioid-mediated ERK activation.