Example sentences for: roscovitine

How can you use “roscovitine” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • We determined whether the inhibition of transcription is specific to flavopiridol by comparing gene expression profiles of flavopiridol-treated cells with those of cells treated with the CDK inhibitors roscovitine and 9-nitropaullone.

  • 9-nitropaullone, the most potent member of a novel class of the paullone CDK inhibitor family, inhibits CDK1/cyclin B at 10-fold lower concentrations than flavopiridol and roscovitine [ 22, 23, 24].

  • Roscovitine is a purine derivative that inhibits CDK1, CDK2 and CDK5 and blocks cell-cycle progression both in late G1/early S and in M phase [ 18, 19, 20, 21].

  • Actinomycin D, roscovitine, phorbol ester and lipopolysaccharide (LPS) were purchased from Calbiochem.

  • As shown in Figure 1c, the gene expression changes caused by roscovitine and 9-nitropaullone were different from those of flavopiridol, and only flavopiridol globally reduced mRNA levels.


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