Words similar to ros
Example sentences for: ros
How can you use “ros” in a sentence? Here are some example sentences to help you improve your vocabulary:
A number of studies provide evidence that the luteolytic process may involve a rapid and sustained increase in ROS [ 58 59 ] . Other studies demonstrate that luteal regression is associated with a dramatic decrease in the mRNAs encoding enzymes responsible for regulating the intracellular redox state [ 60 ] . Death induced by TNFα is also reportedly mediated by an increase in ROS, an event correlated with a marked decrease in the vital intracellular ROS scavenger GSH.
In conclusion, TNFα activates several stress-activated signaling pathways that may facilitate GSH efflux, and thus increase ROS and subsequent cell death.
Our previous study showed that functional decline of mitochondria appears in the SOD1 G93Amice as early as 60 to 100 days of age [ 22 ] . This precedes the peak of mitochondrial vacuolation and the onset of the disease by two to three months [ 15 ] . Mitochondrial dysfunction can lead to energy deficiency and ionic imbalance [ 68 ] , elevated ROS and oxidative damage [ 69 ] , and increased sensitivity of neurons to excitotoxicity [ 19 70 71 72 ] . These effects could precipitate MVISE, which trigger cell death programs by releasing pro-apoptotic proteins resided in the mitochondrial intermembrane space, such as cytochrome c, AIF, SMAC/DIABLO, endo G and Htra/Omi [ 73 ] . The absence of cytochrome c in the porous large vacuoles and the presence of cytochrome c in the small vacuoles (Fig.
The second set of observations indicate that reactive oxygen species (ROS) activate PLD2 in a PKC-dependent manner [ 9 ] . There is much evidence that ROS generation is upregulated in AD brain [ 42 ] . Thus, it is possible that PLD2 may be activated in this disease resulting, perhaps, in dysregulation of PC metabolism.
Finally, generation of ROS during phagocytosis has been implicated in inactivation of lysosomal enzymes [ 13 14 ] . It is conceivable that an elevation of lysosomal pH to as high as 6.5-7.
Loading...