Example sentences for: roles

How can you use “roles” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Building on global changes that are impacting society on a variety of levels, GAO's strategic plan develops a comprehensive and focused structure of longterm goals and objectives to support the Congress in its legislative, oversight, and investigative roles.

  • The amino acid residues at position -1, 2, 3 and 6 of the α helix form base contacts with DNA [Reviewed in [ 49 ] ]. The amino acid sequences of the zinc finger pairs among the ZAS proteins are highly conserved [Reviewed in [ 25 ] ]. The conservation of the zinc fingers from invertebrate to vertebrate species and their common DNA binding target sequences suggest that these proteins may play similar physiological roles in diverse organisms.

  • TNFα and TNFβ have been extensively studied and are involved in immune and pro-inflammatory responses, playing an important role in host defenses against infection and other disease states [ 4 5 6 7 ] . The biological effects of TNFα and TNFβ are mediated through the two membrane associated receptors, TNFR1 (p55) and TNFR2 (p75), that are expressed on the target cells [ 8 9 ] . The postulated pathogenic roles for TNF include sepsis and other bacterial and viral pathologies [ 10 11 12 ] , certain cancers [ 13 ] , metastasis [ 14 ] and chronic autoimmune disorders such as rheumatoid arthritis [ 15 16 ] , multiple sclerosis [ 17 ] and Crohn's disease [ 18 ] . It is worth noting that TNFα mutants have been identified that selectively bind TNFR1.

  • They noted that many boards are reassessing their roles and responsibilities and, at this time, it is difficult to determine what is working and what is not working.

  • This view, in fact, conceals a number of quite different roles for water-channel activity, involving the regulation of water flux and homeostasis at the subcellular, transcellular, tissue and whole-plant levels.


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