Words similar to rofecoxib
Example sentences for: rofecoxib
How can you use “rofecoxib” in a sentence? Here are some example sentences to help you improve your vocabulary:
Overall 252/464 patients (54%) given rofecoxib 50 mg had at least 50% maxTOTPAR over six hours, compared with 24/211 patients (11%) with placebo.
One of them was David Graham, Associate Director in the United States Food and Drug Administration's (FDA's) Office of Drug Safety, whose research on rofecoxib (Vioxx) pointed to the serious cardiovascular risks of the drug [1].
The efficacy of rofecoxib in these five classical clinical analgesic assays is in contrast to two randomized comparisons of rofecoxib with placebo when given before the operation in adults [ 36 ] and children [ 37 ] . The methodological difficulties and lack of effect of preemptive analgesia have been pointed out previously [ 38 39 ] . In these two trials additional difficulties were the large between-individual variation in morphine consumption in adults [ 36 ] , and the use of a novel (unlicensed) syrup formulation of rofecoxib in children [ 37 ] . Lack of a demonstrable analgesic effect in preemptive studies does not negate a substantial postoperative effect when patients both have pain and can swallow.
The number of patients with at least 50%maxTOTPAR was then used to calculate relative benefit and NNT for rofecoxib versus placebo.
This Food and Drug Administration (FDA) safety officer raised concerns about the cardiovascular side effects of rofecoxib (Vioxx) and other Cox-2 inhibitors.
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