Words similar to rna-dependent
Example sentences for: rna-dependent
How can you use “rna-dependent” in a sentence? Here are some example sentences to help you improve your vocabulary:
RSV is a member of the Pneumovirus genus in the Paramyxoviridae family, and contains a nonsegmented negative-stranded RNA genome of about 15 kb [ 5 ] . The minimal viral RNA-dependent RNA polymerase (RdRP) consists of two virally encoded proteins, the large protein L and the phosphoprotein P [ 6 7 8 ] , and a third viral protein, M2-1 (22K), contributes RNA antitermination function and optimal processivity [ 9 ] . In addition to these viral proteins, the RdRP also requires cellular actin.
Genetic heterogeneity is a hallmark of RNA viruses in general, and the hepatitis C virus (HCV) in particular, due to the lack of fidelity of viral RNA-dependent RNA polymerases [ 1 2 ] . In HCV, this genetic diversity has been organized into six major genotypes and numerous subtypes (over 80).
Indeed, it has been estimated that the deleterious mutation rate in viruses that replicate using RNA polymerases (either reverse transcriptase in the case of retroviruses or RNA-dependent RNA polymerase for other RNA viruses) is on the order of one error per replication cycle, so that many of the viral progeny produced by replication are defective (Elena and Moya 1999).
In addition to forging a link between RNA virus resistance and PTGS, this study included a remarkably prescient model for PTGS that featured an RNA-dependent RNA polymerase (RDR), small RNAs, and dsRNA, all of which were later found to be important for the RNAi.
Thus, these comparisons identify previously undetected prokaryotic homologs of the eukaryotic RDRPs, the YRH proteins, which probably also have RNA-dependent RNA polymerase activity.
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