Words similar to risperidone
Example sentences for: risperidone
How can you use “risperidone” in a sentence? Here are some example sentences to help you improve your vocabulary:
Clozapine, on the other hand, was observed previously to increase bladder capacity and pressure threshold [ 6 7 ] . Olanzapine had no effect on bladder peak pressure during contraction and only the highest dose of risperidone showed an increase in pressure (119% of control).
The physiological significance is unclear since the 10 mg/kg dose is well above the clinically effective doses of risperidone.
In cats, serotonin antagonists caused a decrease in bladder capacity [ 43 ] however in anesthetized rats, serotonin antagonism did not have an effect on micturition [ 44 ] . Recently, a selective 5-HT1A receptor antagonist (WAY-100635) was reported to inhibit bladder contractions in rats [ 45 ] yet another report only observed an increase in the pressure threshold [ 46 ] . Olanzapine and risperidone have only low to modest affinity for the 5-HT1A receptor, and higher affinities for the 5-HT2A and 5-HT2C receptors [ 11 12 ] . Serotonin 5-HT2 and 5-HT3 receptors facilitate pudendal reflexes in the cat [ 47 48 ] , therefore it is possible that antagonism of these receptors may block the EUS in the anesthetized rat.
The increase in pressure after the highest dose of risperidone was interesting and was also observed following electrical stimulation of the pelvic nerve suggesting a possible peripheral mechanism.
Finally, while risperidone had no effect on the amplitude of the EMG bursts occurring the expulsion phase (Fig 1; Fig 6D), olanzapine abolished bursting of the EMG at 1.0 mg/kg in all animals tested (Fig 1H; 6D).
Loading...