Words similar to rhoa
Example sentences for: rhoa
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Interestingly, RSV infection of HEp-2 cells also led to the formation of actin stress fibers and activation of the small cellular GTPase RhoA, a modulator of actin filamentation [ 14 15 16 17 ] . Inhibition of RhoA or its interaction with F resulted in the inhibition of syncytium as well as stress fiber formation and the second cycle of infection [ 14 ] . Recombinant F also activated RhoA in the absence of any other viral protein [ 17 ] . Based on these results, it was inferred that stress fiber formation might be important in some aspects of RSV infection, such as virus spread, elaboration of cytokines from infected cells, and contraction of airway muscles that promotes asthma.
Members of this family include RhoA, RhoB, RhoC (which are isoforms), Cdc42, G25K, RhoG, Rac1, Rac2, and TC10 (reviewed in [ 34 ] ). In fibroblast models, these GTPases have been proposed to act in a concerted hierarchy to coordinately regulate distinct morphological features.
Immunolocalization of the GTPase RhoA was performed to determine if inactivation by C3 exoenzyme caused spatial redistribution of RhoA in HPB-ALL.
However, RhoA appeared to be in relatively larger clusters distributed along the aberrant pseudopodial structures with no diffuse staining observed (figure 4, right panels, arrows).
C3 exoenzyme was purified as previously described [ 25 ] . Anti-β1 integrin mAb 33B6 and anti α4β1 integrin mAb 19H8 were generated in this laboratory and have been previously described [ 27 28 ] . Rabbit polyclonal anti-Cdc42, -Rac1, -Rac2, -RhoA, and mouse monoclonal anti-Ras, were purchased from Santa Cruz Biotechnology (Santa Cruz, CA).
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