Words similar to rhoa
Example sentences for: rhoa
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ADP-ribosylation of Rho proteins by C3 exoenzyme prevents neurite retraction in the specialized growth cone of developing neurons, and in fact promotes neurite outgrowth in the same fashion as microinjection of purified dominant negative RhoA T19N [ 39 ] . In these instances, neuronal N1E-115 cell outgrowth induced by inactivation of RhoA was mimicked by microinjection of Rac1- or Cdc42-GST fusion proteins, and could be abolished by coinjection of dominant negative Cdc42 T17Nor Rac1 T17N [ 39 ] . From these results, the authors concluded that inactivation of RhoA by C3 exoenzyme treatment resulted in the activation of Rac1 and Cdc42 GTPases, suggesting the mutually exclusive function of RhoA and Rac1/Cdc42.
Inactivation of Rho by electroporation of C3 exoenzyme did not seem to cause a large overall redistribution of RhoA in spread HPB-ALL.
Actin filament elongation would continue and RhoA dependent retraction of filamentous actin would be abrogated.
Immunolocalization studies of RhoA in C3 treated HBP-ALL cells spreading on fibronectin showed no gross differences in RhoA distribution, however clusters of RhoA were more delineated along the finger-like dendritic processes of the C3 treated cells.
Interestingly, RSV infection of HEp-2 cells also led to the formation of actin stress fibers and activation of the small cellular GTPase RhoA, a modulator of actin filamentation [ 14 15 16 17 ] . Inhibition of RhoA or its interaction with F resulted in the inhibition of syncytium as well as stress fiber formation and the second cycle of infection [ 14 ] . Recombinant F also activated RhoA in the absence of any other viral protein [ 17 ] . Based on these results, it was inferred that stress fiber formation might be important in some aspects of RSV infection, such as virus spread, elaboration of cytokines from infected cells, and contraction of airway muscles that promotes asthma.
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