Words similar to rheumatoid
Example sentences for: rheumatoid
How can you use “rheumatoid” in a sentence? Here are some example sentences to help you improve your vocabulary:
Moreover, the Sa antigen, which, unlike (pro)filaggrin, is detectable in rheumatoid synovium, has recently also been shown to be citrullinated [ 18].
In addition, auto-antibodies against actin, vinculin, integrins, or fibronectin could also form complexes with mactinin [ 24 25 ] . Our results suggest that mactinin is bound to immune complexes in rheumatoid arthritis joint fluid, which prevents its binding to the antibody-matrix during the isolation procedure.
Therefore, the defective generation of IL-4 producers from RA synovial fluid under conditions that induced IL-4-producing effector cells from blood memory T cells suggested that the rheumatoid microenviroment played an important role in selecting or modifying the precursor effector memory population.
The selective suppression of Th1 cell activity is believed to be due to IL-10 inhibition of IL-12, a differentiation factor for Th1 cells [ 11 12 ] . The release of reactive oxygen and nitrogen intermediates by macrophages is also suppressed by IL-10 [ 13 14 ] . In addition, IL-10 stimulates the production of cytokine inhibitors such as IL-1 receptor antagonist [ 15 ] . In patients with rheumatoid arthritis, IL-10 is produced by synovial membrane cells and is found at high levels in the synovial fluid [ 16 17 ] . It has been shown that suppression of IL-10 production by synovial cells is associated with increased levels of IL-1 and TNF-α, suggesting that IL-10 plays a suppressive role in rheumatoid arthritis joints [ 16 ] . It was also observed that IL-10 directly stimulated proteoglycan synthesis and reversed the cartilage degradation induced by activated mononuclear cells [ 18 ] . These immunosuppressive activities indicate that IL-10 is a potential therapeutic approach for autoimmune diseases.
In the present study we analyzed cytokine (IL-2, IL-4, IL-6, IL-10, IL-13, IFN-γ , TNF-α , and LT-α ), activation marker (CD154 [CD40 ligand] and TRANCE - also called receptor activator of nuclear factor κ B ligand [RANKL] or osteoclast differentiation factor [ODF]), and chemokine receptor expression by individual CD4 +memory T cells isolated from rheumatoid synovium and blood.
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