Words similar to rgs
Example sentences for: rgs
How can you use “rgs” in a sentence? Here are some example sentences to help you improve your vocabulary:
RGS3 0.2 M.O.I.
For instance, RGS4 and RGS-GAIP [ 11 ] , RGS3 [ 9 ] , RGS2 [ 46 ] , and RGS7 (our unpublished findings) all bind Gqα, the established G protein that transduces GnRH receptor signaling [ 38 ] . Nevertheless, RGS2 and 4 [ 9 ] , and RGS-GAIP and RGS7 (our unpublished data) are weak or null inhibitors of GnRH receptor signaling.
The accumulated data provide particular support for DISC1 , DTNBP1 , NRG1 , and RGS4 . Each of these genes has received support from multiple lines of evidence with imperfect consistency: 1) The case for each of these as a candidate gene for schizophrenia is supported by linkage studies; 2) The preponderance of association study findings provides further support; 3) mRNA from each gene is expressed in the prefrontal cortex as well as in other areas of the brain; and 4) Additional neurobiological data link the functions of these genes to biological processes thought to be related to schizophrenia.
Binding studies of recombinant RGS3-GST fusion protein to 35S-Met-Gα-proteins were performed as detailed [ 9 ] . Glutathione-coupled beads were used to select 35S-Gα proteins bound to RGS3-GST, and were then eluted for separation by SDS/PAGE [ 9 ] . The amount and molecular size of 35S-Gα protein were determined using a Phosphor imaging device (Molecular Dynamics).
With respect to the G protein as a locus for modulation of GnRH receptor signaling, we reported earlier that experimental expression of RGS3 but not RGS1, 2, or 4 in GnRH receptor expressing COS-1 cells suppressed GnRH-stimulated IP 3 production [ 9 ] . In the current report, we present evidence strengthening the hypothesis of a regulatory role for RGS3 in GnRH receptor signaling: adenovirus-mediated expression of RGS3 in normal pituitary gonadotropes profoundly inhibited GnRH-stimulated LH secretion and 3H-inositol phosphate accumulation.
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