Words similar to retrograde

Example sentences for: retrograde

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One process inhibited by BDM is the centripetal flow of actin from the leading edge into the cell body, known as retrograde flow [ 11 12 ] . Retrograde flow is thought to be driven by a "push-pull" mechanism of polymerization of actin at the leading edge of the cell and contractile activity of myosin motor proteins [ 13 14 ] . Formation of new actin filaments is predominantly mediated by the nucleation activity of the Arp2/3 complex [ 15 ] . Members of the WASP/WAVE family of proteins, among others, stimulate and regulate the Arp2/3 complex for spatial and temporal control of filament nucleation [ 15 ] . Localization of these proteins to the leading edge, though not completely understood, is probably mediated through their interactions with the actin cytoskeleton itself and membrane-associated binding partners [ 15 16 ] .
After BDM treatment, we observed a uniform decrease in fluorescence suggestive of dissociation and diffusion of Arp3, rather than de-localization driven by retrograde flow [Figure 5A].
And what can this tell us about the mechanism of retrograde flow?
If the pathway had evolved in a retrograde direction, the Horowitz theory would postulate that GshB arose to take advantage of γ-Glu-Cys present in the environment.
A similar situation occurs for pathways evolving in a retrograde direction.