Words similar to resuppression
Example sentences for: resuppression
How can you use “resuppression” in a sentence? Here are some example sentences to help you improve your vocabulary:
We followed a study design with step-wise increases in the length of TI cycles to address potential safety concerns (resuppression was confirmed after shorter TIs before longer interruptions were initiated) and the hypothesis that sequential viral replication intervals would stimulate viral control and a delay in time to viral rebound.
However, based on the lack of association between viral resistance detected off-drug shortly after TI and resuppression by the same regimen in all patients, it remains undetermined to what extent TIs favor the detection of archived mutations in chronically suppressed patients and to what extent these mutations are a signal for a future therapy failure.
Further, we observed durable resuppression of plasma viral RNA level in many patients who had drug-resistance mutations off therapy that would otherwise be expected to affect part of their treatment regimen when reinitiated (see Table S1).
It is of interest to note that despite the large amount of research activity on TIs in patients with suppressed chronic infection and the hundreds of monitored interruptions studied to date, only limited cases of development of clinical resistance (as evidenced by a lack of viral resuppression following therapy reinitiation) have emerged, in contrast to the multiple reports of detection of viral sequences off ART associated with resistance as shown in this study and others [11,19,29,30,39,40].
Phase II procedures for both arms included the following: (1) monitoring for patient study withdrawal criteria as described in phase I, (2) determining time to primary end point of a viral load greater than 5,000 copies/ml, (3) monitoring until the time of therapy reinitiation at a viral load greater than 30,000 copies/ml for three consecutive time points, and (4) after reinitiation of therapy, follow-up on therapy to confirm resuppression to less than 50 copies/ml at 6, 10, and 14 wk on therapy.
Loading...