Words similar to resuppression
Example sentences for: resuppression
How can you use “resuppression” in a sentence? Here are some example sentences to help you improve your vocabulary:
when measured between arms before the open-ended TI (see Figure 4), nor following resuppression after monitored TI reinitiation cycles in the repeated interruptions arm (see Figure 5).
In contrast, our strategy mandated resuppression of viral replication to less than 50 copies/ml before each TI and presents the first comparison of viral replication during a final open-ended interruption of therapy between patients randomized to complete three sequential TIs or stay under continuous therapy.
Earlier reports on TI strategies in patients with chronic HIV infection include multiple pilot or single-arm study designs centered on the effects on viral control by comparison with pre-therapy periods, detection of resistance mutations without parallel follow-up of a continuously treated arm, and inclusion of variable criteria regarding viral resuppression before proceeding with repeated TIs [11,12,14,16].
We followed a study design with step-wise increases in the length of TI cycles to address potential safety concerns (resuppression was confirmed after shorter TIs before longer interruptions were initiated) and the hypothesis that sequential viral replication intervals would stimulate viral control and a delay in time to viral rebound.
Phase II procedures for both arms included the following: (1) monitoring for patient study withdrawal criteria as described in phase I, (2) determining time to primary end point of a viral load greater than 5,000 copies/ml, (3) monitoring until the time of therapy reinitiation at a viral load greater than 30,000 copies/ml for three consecutive time points, and (4) after reinitiation of therapy, follow-up on therapy to confirm resuppression to less than 50 copies/ml at 6, 10, and 14 wk on therapy.
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