Words similar to responsiveness
Example sentences for: responsiveness
How can you use “responsiveness” in a sentence? Here are some example sentences to help you improve your vocabulary:
In the colon, loss of the type II TGF-β receptor occurs at the late adenoma to carcinoma transition [ 49], suggesting that early premalignant lesions retain TGF-β responsiveness and would be amenable to interventions that enhance TGF-β activity.
Despite these efforts to be insure that the system was optimized in order to detect a steroid-mediated alteration of Stx responsiveness, the concern still exists that this system may not really reflect the influences of sex steroids in vivo.
The differences in androgen responsiveness we have observed between normal genital fibroblasts and prostate cancer epithelial cells in vitro might reflect the responses seen in vivo . Prostate epithelial cells retain exquisite sensitivity to androgen throughout life.
Among genes that are stimulated by FSH/cAMP during the period of maturation of Sertoli cells (15 to 20 days of age in rats), are several subunits of cAMP-dependent protein kinase (PKA), the serine/threonine kinase mainly responsible for the downstream effects of FSH [ 15 ] . Expression of the RIIβ regulatory subunit of cAMP-dependent protein kinase is highly induced (50-fold) at the mRNA level in primary cultures of rat Sertoli cells as a late response to cAMP peaking at 12 hours [ 16 ] . We have demonstrated that expression of CAAT/Enhancer binding protein β (C/EBPβ) is induced by cAMP with rapid kinetics in Sertoli cells, and that C/EBPβ is responsible for induction of late response genes like the RIIβ-gene [ 17 ] . The RIIβ promoter contains a conserved E-box/HLH element in the basal promoter localized at -280 to -275 relative to the functional ATG [ 18 ] . This element is shown to be important for cAMP-responsiveness in granulosa cells, and it has been shown to bind both USF and Myc in CHO and NB2a cells [ 18 19 ] . In this work, we show that USF isoforms may regulate cAMP responsiveness of the RIIβ promoter by modulating the effect of C/EBP, and that the formation of USF isoforms may be regulated by cAMP in Sertoli cells.
The activation of CaMKII then catalyzes the phosphorylation of AMPA-receptors and enhances AMPA receptor responsiveness [ 37, 39, 40, 60].
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