Words similar to reserpine

Example sentences for: reserpine

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The literature surrounding norepinephrine and its role in the development of iron deficient hypertrophy documents the following facts: 1) prolonged iron deficiency causes cardiac hypertrophy [ 11 12 13 14 15 16 17 23 ] , 2) the pool of stored norepinephrine in the heart is decreased with iron deficiency [ 17 21 ] , 3) plasma and urine concentrations of norepinephrine are increased with iron deficiency [ 19 20 21 22 68 ] , and 4) chronic administration of reserpine (which depletes norepinephrine) prevents the development of iron deficient hypertrophy [ 12 ] , but not hypertrophy that results from aortic banding [ 23 ] . This, combined with other studies that relate chronic adrenergic stimulation to hypertrophy, led Rossi to the conclusion that iron deficiency hypertrophy was caused by chronic sympathetic stimulation.
Some studies have also found that P-gp antagonists such as VRP, cyclosporin A and reserpine could induce MDR1/P-gp expression in the colon carcinoma cell line LS180-Ad50 [ 31, 32].
Evidence to support this view includes the observations of increased levels of norepinephrine in plasma and urine, and decreased norepinephrine content in the iron deficient heart [ 19 20 21 22 ] . Rossi [ 23 ] , after finding that reserpine administration prevented the development of this hypertrophy, even suggested that norepinephrine is the causal agent in the pathology.