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Example sentences for: removes
How can you use “removes” in a sentence? Here are some example sentences to help you improve your vocabulary:
3 region to which RASSF1A maps undergoes deletions in many solid tumor types, including GCTs [ 9 ] . RASSF1A encodes a splice variant of human RAS effector homologue, which interacts with the XPA protein and functions as a negative regulator of cell growth [ 16 17 ] . RASSF1A has been shown to be inactivated by promoter methylation in a variety of tumor types [ 16 17 18 19 ] . The 17q21 and 17p13 regions, to which BRCA1 and HIC1 map, respectively, also have been characterized by high frequency of LOH in GCT [ 9 ] . The BRCA 1 gene plays critical roles in DNA repair and recombination, cell cycle checkpoint control, and transcription and has been shown to be hypermethylated in breast-ovarian cancer [ 4 ] . The HIC1 gene is also often hypermethylated in many human cancers [ 20 21 22 ] . The DNA repair gene MGMT encodes O(6)-methylguanine-DNA methyltransferase and this enzyme effectively removes DNA adducts formed by alkylating agents [ 23 ] . Epigenetic inactivation of the MGMT gene was reported in a wide variety of cancers [ 24 25 ] . Also, a low frequency of methylation of the APC , RARB , and FHIT genes was detected in NSGCTs.
The final rule removes the effective competitive opportunities test and replaces it with an open entry standard.
A long terminal repeat from a human endogenous retrovirus (HERV) was shown to drive the expression of an intergenic transcript from an unknown gene named HERV-HLTR associating 1 (HHLA1) and human otoconin-90 (OC90) to produce a transcript that is highly expressed in teratocarcinoma cells but not in normal human tissues or cell lines [ 33 ] . In the mouse, a Prion-like downstream gene named doppel (Dpl) was found to have an intergenic transcript that is upregulated in Prion-deficient mice [ 34 ] . The deletion of the Prion gene in these mice removes the splice acceptor site of exon 3, causing the normal Prion transcript to skip the deleted exon and inadvertently upregulate the normally low-abundance intergenic transcript by forcing it to splice more often to the doppel gene.
The ndr1-1 mutant is an unambiguous null mutant in that a deletion removes most of the coding region and the proximal promoter region [ 6 ] . However, none of the characterized npr1 mutants have a large deletion [ 15 16 ] . As such, attempts to define allelic series have relied upon the level of residual function associated with these mutants in assays of gene expression or fungal disease resistance [ 15 16 ] . However, the complexity of signaling leading to these outputs complicates analyses of these phenotypes.
4. This is also consistent with the suggestion, made in a recent report showing that cystic fibrosis isolates of P. aeruginosa had lipid A isoforms derivatized with aminoarabinose (or palmitate), that these structural modifications could enhance resistance to cationic antimicrobial peptides [ 61 ] . Although the acyl chains of lipid A might also provide alternative binding sites for protegrin, the orientation of lipid A on the HPA sensor chip ("butter-side down") probably removes them from consideration, at least under our study conditions.
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