Words similar to remissions
Example sentences for: remissions
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The HL-60 human promyelocytic leukemia cell line responds in culture to sub-micromolar concentrations of retinoic acid ( all-trans and 13-cis ) by undergoing terminal differentiation to a granulocytic cell with the ability to phagocytose and reduce nitroblue tetrazolium [ 28 ] . The response to retinoic acid in HL-60 cells is dependent on the expression of the retinoic acid receptor RAR α [ 29 ] . The use of all-trans retinoic acid in differentiation therapy for patients with acute promyelocytic leukemia has resulted in prolonged, complete remissions when combined with cytotoxic chemotherapy, and may provide complete, long-term remissions as a single agent [ 30 ] .
Gleevec has been shown to induce clinical, hematological and molecular remissions for CML patients [ 4 ] . It cross-reacts with two other important growth factor receptors containing tyrosine kinase domains, c-kit and PDGF receptors, that play important roles in growth and proliferation of a variety of cell types [ 5 ] . C-kit (also known as CD117) is frequently mutated in gastrointestinal stromal tumor (GIST), and the mutated c-kit shows higher tyrosine kinase activity.
8% [1], with onset typically ranging from adolescence to early adulthood and a course of illness typified by exacerbations, remissions, and substantial residual symptoms and functional impairment [2].
(Nasar gives an interesting account of just how rare such remissions are among those diagnosed with schizophrenia.)
He speculated that if many dependent patients can have spontaneous remissions, then research on whether brief interventions could help them seems warranted.
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