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Example sentences for: remissions
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The HL-60 human promyelocytic leukemia cell line responds in culture to sub-micromolar concentrations of retinoic acid ( all-trans and 13-cis ) by undergoing terminal differentiation to a granulocytic cell with the ability to phagocytose and reduce nitroblue tetrazolium [ 28 ] . The response to retinoic acid in HL-60 cells is dependent on the expression of the retinoic acid receptor RAR α [ 29 ] . The use of all-trans retinoic acid in differentiation therapy for patients with acute promyelocytic leukemia has resulted in prolonged, complete remissions when combined with cytotoxic chemotherapy, and may provide complete, long-term remissions as a single agent [ 30 ] .
The best example of such an approach is treatment with UV-A and psoralens, as well as UV-B, which result in depletion of APCs and produce one of the most long-lasting remissions of the disease which might last in some instances for as long as 6 months [ 31 32 ] A key antigenic marker of skin APCs is CD1a.
8% [1], with onset typically ranging from adolescence to early adulthood and a course of illness typified by exacerbations, remissions, and substantial residual symptoms and functional impairment [2].
The coverage of the investigation has been like the course of a long, fatal illness, with many remissions and recurrences.
Gleevec has been shown to induce clinical, hematological and molecular remissions for CML patients [ 4 ] . It cross-reacts with two other important growth factor receptors containing tyrosine kinase domains, c-kit and PDGF receptors, that play important roles in growth and proliferation of a variety of cell types [ 5 ] . C-kit (also known as CD117) is frequently mutated in gastrointestinal stromal tumor (GIST), and the mutated c-kit shows higher tyrosine kinase activity.
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