Words similar to regions
Example sentences for: regions
How can you use “regions” in a sentence? Here are some example sentences to help you improve your vocabulary:
The outer surface of the coiled-coil contains grooves into which three heptad repeat regions from the C-terminal part of the gp41 ectodomain pack, resulting in a stable six-helix bundle [ 42 45 46 47 48 49 50 51 52 53 54 ] . The six-helix bundle structure can be detected by specific antibodies [ 14 20 43 55 ] .
3 region to which RASSF1A maps undergoes deletions in many solid tumor types, including GCTs [ 9 ] . RASSF1A encodes a splice variant of human RAS effector homologue, which interacts with the XPA protein and functions as a negative regulator of cell growth [ 16 17 ] . RASSF1A has been shown to be inactivated by promoter methylation in a variety of tumor types [ 16 17 18 19 ] . The 17q21 and 17p13 regions, to which BRCA1 and HIC1 map, respectively, also have been characterized by high frequency of LOH in GCT [ 9 ] . The BRCA 1 gene plays critical roles in DNA repair and recombination, cell cycle checkpoint control, and transcription and has been shown to be hypermethylated in breast-ovarian cancer [ 4 ] . The HIC1 gene is also often hypermethylated in many human cancers [ 20 21 22 ] . The DNA repair gene MGMT encodes O(6)-methylguanine-DNA methyltransferase and this enzyme effectively removes DNA adducts formed by alkylating agents [ 23 ] . Epigenetic inactivation of the MGMT gene was reported in a wide variety of cancers [ 24 25 ] . Also, a low frequency of methylation of the APC , RARB , and FHIT genes was detected in NSGCTs.
Thus, one needs to apply a post hoc test to the ANOVA results to determine which regions, if any, show differences from others.
Epigenetic hypermethylation in the promoter regions of a number of genes has been recognized as an important change in the development of human cancer [ 9 ] . A growing number of cancer-related genes have been identified to harbor methylation of cytosine residues in CpG-rich promoter sequences.
Pairwise alignment of homologous genomic regions between D. melanogaster and individual non-melanogaster species was performed using default parameters of the AVID global alignment tool [ 42].
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