Words similar to regenerate
Example sentences for: regenerate
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Neurons with axons in the peripheral nervous system can successfully regenerate when injured [ 22 ] . This is in part due to an environment permissive for axonal growth but also due to the upregulation of regeneration-associated genes (RAGs) which increase intrinsic growth capacity [ 23 ] . Three examples of RAGs are GAP-43 and CAP-23 [ 24 ] and sprp1A [ 8 ] . We now find several other potential candidates including; α2 macroglobulin, CLP36, and VGF all of which have been described to promote neurite outgrowth or interact with the cytoskeleton in a way that may promote regeneration (see Table 4 [additional file 3] for references).
LIF and CNTF stimulate muscle regeneration in vivo [ 62 63 ] , as do other growth factors; such as insulin-like growth factor [ 64 65 ] . The power of LIF to regenerate muscle is seen in dystrophin null mdx mice, where exogenous LIF regenerates atrophied diaphragm muscle [ 66 ] . LIF induced signaling appears to be essential in muscle development as seen by muscle atrophy in the absence of LIFR on E18.
This belief was based on the well-documented failure of injured axons to regenerate within the central nervous system (CNS) [ 1] and reinforced by studies showing that neurons attach poorly to white matter in vitro [ 2, 3, 4, 5, 6, 7, 8, 9].
Although neurons appear to possess the intrinsic capacity to regenerate their axons, this capacity may not be retained indefinitely following injury.
This was unexpected because, in contrast to peripheral nerves, axons of the adult, mammalian central nervous system typically fail to regenerate following injury.