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Example sentences for: refusers
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Case-control studies are applicable with special considerations for cancer screening [ 22 ] . Periodic Screening Evaluation (PSE) is a method for using data from subjects of various age who receive at least two regularly scheduled screenings to estimate the reduction in cancer mortality from periodic screening over a range of ages [ 23 24 ] . The main assumptions of PSE are (1) once a cancer is detectable on screening it would be detectable on later screenings (2) given age, year of birth adds no information for predicting the detection rate on the first screen, (3) no selection bias in using refusers to estimate survival from detection in the absence of screening.
To avoid this assumption (and the need to collect data from refusers), we estimated the cancer mortality rate following detection in the absence of screening by the cancer mortality rate in interval cancers.
PSE involves three steps: (1) estimate the age-specific incidence of cancer associated with different types of detection: first screen, interval between screens, subsequent screen, refusers, and
Previous approaches [ 1 2 3 ] used data from refusers, substituting m
We also compared the PSE estimates with estimates based on a comparison of outcomes in the two randomized groups, adjusting for refusers and mitigating the effect of dilution after stopping screening [ 17 ] . It is important to bear in mind that the two estimates are answering different questions.