Example sentences for: refractory

How can you use “refractory” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In controlled clinical trials, the leading causes of death were multiple organ failure, refractory septic shock, and respiratory failure (Table 2).

  • In contrast, no significant change in TBP and TAF II 135 is seen in extracts from T-RA treated RXRα -/-RARγ -/-cells, in which the RARγ gene has also been disrupted [ 50, 51] and which are known to be refractory to T-RA induced differentiation (Fig.

  • Serotonin antagonists have been very effective in treating chemotherapy-associated nausea (eg, ondansetron) [ 58 ] . They have been reported to be useful for refractory nausea of diverse types but are typically tried only when other medications have failed.

  • Refractory cases of nausea and vomiting often require combinations of medications from different classes.

  • Malignant tumor cells frequently show deregulation and hyperactivation of signalling pathways, one of which is represented by the TGFβ signal transduction pathway [ 1 ] . TGFβ has been shown to potently inhibit proliferation of most epithelial, endothelial and hematopoietic cells [ 2 ] . However, during tumor progression malignant cells may become refractory to TGFβ-mediated cell cycle arrest.


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