Words similar to refractory

Example sentences for: refractory

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Malignant tumor cells frequently show deregulation and hyperactivation of signalling pathways, one of which is represented by the TGFβ signal transduction pathway [ 1 ] . TGFβ has been shown to potently inhibit proliferation of most epithelial, endothelial and hematopoietic cells [ 2 ] . However, during tumor progression malignant cells may become refractory to TGFβ-mediated cell cycle arrest.
The survival benefit associated with drotrecogin alfa (activated) appears to be related to a reduction in the number of deaths from refractory septic shock and respiratory failure.
In contrast, no significant change in TBP and TAF II 135 is seen in extracts from T-RA treated RXRα -/-RARγ -/-cells, in which the RARγ gene has also been disrupted [ 50, 51] and which are known to be refractory to T-RA induced differentiation (Fig.
They extended their earlier findings that EGFR mutations (which were found in 17 of the tumors) were associated with sensitivity to the kinase inhibitors, and found that tumors that had mutations in KRAS (a total of nine) were refractory (i.e.
Unlike the other cells in the population, these cells do not differentiate into parietal endoderm showing that they are refractory to bt 2 cAMP.