Example sentences for: refractory

How can you use “refractory” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • 10B) showing that these cells are refractory to the differentiating effect of bt 2 cAMP.

  • Staphylococcus aureus is the most common cause of osteomyelitis, a disease often refractory to treatment and subject to recurrence.

  • All of these cell lines have been isolated from patients with advanced prostate carcinomas that have become refractory to androgen deprivation therapy [ 5, 6, 7].

  • M6P/IGF2R allelic loss would therefore result in enhanced cellular bioavailability of this potent growth factor, thereby potentially increasing both cell proliferation and resistance to apoptosis [ 29 ] . The M6P/IGF2R also facilitates the activation of TGFβ, a potent cell growth inhibitor that is secreted in an inactive form (reviewed in [ 15 16 ] ). M6P/IGF2R mutation is therefore one mechanism by which cancer cells can become refractory to TGFβ's mitoinhibitory effect.

  • Enrique Lerdau gives examples of German Schuttelreime [XX,3] but finds them refractory in English.


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