Words similar to refractory
Example sentences for: refractory
How can you use “refractory” in a sentence? Here are some example sentences to help you improve your vocabulary:
Although imatinib inhibits different kinases in various diseases (BCR-ABL in CML, KIT or PDGFR-alpha in gastrointestinal stromal tumors [GISTs], and PDGFR-alpha in hypereosinophilic syndrome [HES]) (reviewed in [14]), some tumors that become refractory to treatment with imatinib appear to have analogous secondary mutations in the kinase-coding domain of the genes encoding these three enzymes.
- The following case of a 40 yrs old hospice worker, in whom oropharyngeal cancer was diagnosed during pregnancy, may illustrate the procedure of sedation in our PCU but also the difficulties associated with drawing the line in consideration of patients needs, personal intentions and adequacy of sedative procedures for refractory symptom control:
Malignant tumor cells frequently show deregulation and hyperactivation of signalling pathways, one of which is represented by the TGFβ signal transduction pathway [ 1 ] . TGFβ has been shown to potently inhibit proliferation of most epithelial, endothelial and hematopoietic cells [ 2 ] . However, during tumor progression malignant cells may become refractory to TGFβ-mediated cell cycle arrest.
Consistent with this idea, sα i2 was refractory to stable expression even though cells stably expressing α i2 were easily selected (not shown).
In contrast, no significant change in TBP and TAF II 135 is seen in extracts from T-RA treated RXRα -/-RARγ -/-cells, in which the RARγ gene has also been disrupted [ 50, 51] and which are known to be refractory to T-RA induced differentiation (Fig.
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