Words similar to refractory
Example sentences for: refractory
How can you use “refractory” in a sentence? Here are some example sentences to help you improve your vocabulary:
Unfortunately the addition of GM-CSF did not increase the CR rate when it was compared to placebo in a prospective randomized study in patients with relapsed and refractory AML.
We identified 60 lung adenocarcinomas from individual patients with tumors shown to be sensitive or refractory to single-agent gefitinib or erlotinib and evaluated these tumors for mutations in EGFR and KRAS . Collectively, nine of 38 (24%) tumors refractory to either kinase inhibitor had KRAS mutations, while zero of 21 (0%) drug-sensitive tumors had such mutations ( p = 0.02) (Table 1).
If tails are amputated during this refractory period, genes that are normally expressed during the early stages of tadpole tail regeneration, such as BMP4, Msx1 , and Notch-1 , are not expressed.
Though we could not make a clear differentiation between primary (when patients want to be sedated approaching the moment of death) and secondary sedation (when sedation results as a "side-effect" in otherwise refractory symptom control [ 46 ] , it must be clear to all, that the intention of sedation in the terminal and final phase is not a concealed form of euthanasia [ 47 ] . Under ethical aspects the requests for sedation to reduce consciousness to a state of unawareness need an individual and balanced approach, especially when the wish for sedation is not connected with the intolerability of physical or psychological distress This makes it necessary to discuss the problem of "terminal sedation" like other forms of therapeutic and existential support with patients and family members at an early stage in palliative care.
- The following case of a 40 yrs old hospice worker, in whom oropharyngeal cancer was diagnosed during pregnancy, may illustrate the procedure of sedation in our PCU but also the difficulties associated with drawing the line in consideration of patients needs, personal intentions and adequacy of sedative procedures for refractory symptom control:
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