Words similar to refractory

Example sentences for: refractory

How can you use “refractory” in a sentence? Here are some example sentences to help you improve your vocabulary:

Malignant tumor cells frequently show deregulation and hyperactivation of signalling pathways, one of which is represented by the TGFβ signal transduction pathway [ 1 ] . TGFβ has been shown to potently inhibit proliferation of most epithelial, endothelial and hematopoietic cells [ 2 ] . However, during tumor progression malignant cells may become refractory to TGFβ-mediated cell cycle arrest.
However, reports of conversion from cyclosporine to tacrolimus, [ 30 31 ] which are most commonly employed as a rescue agent for refractory acute or chronic rejection or cyclosporine toxicity, suggest that this number is very small.
First, cancers are often detected at a late stage in development, after multiple genetic and epigenetic changes have rendered the cancer metastatic and highly refractory even to harsh treatment.
This finding is in confirmation with other studies, in which besides acute bleeding and gastrointestinal symptoms, distressing dyspnoea, delirium and agitated anxiety also where found to be the main reasons for sedation in end-of-life care [ 32 ] . The adequate treatment and care of patients of patients with otherwise refractory symptoms certainly is a great challenge in palliative care and improvement in this field is needed urgently.
Enrique Lerdau gives examples of German Schuttelreime [XX,3] but finds them refractory in English.