Words similar to redβ
Example sentences for: redβ
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As discussed above, the RecT/Redβ superfamily clearly splits into three distinct families (Fig.
These proteins are known to cooperate with SbcD, nuclease of the calcineurin-like phosphoesterase superfamily and to degrade dsDNA in the 3' → 5' direction generating ssDNA [ 35 36 ] . It seems likely that RecT/Redβ proteins, at least in certain cases, function in conjunction with the SbcCD-pathway, by utilizing the single-stranded regions generated by the SbcCD nuclease.
For example, searches initiated with the Redβ homolog, PF161 protein (Genbank gi: 9836834 amino acids 1 to 188) from Borrelia hermsii [ 18 ] , detected the E. coli RecT protein in the 5 thiteration with significant expectation (e) values (3 × 10 -3).
Rad52 functions in conjunction with the RecA ortholog, the RAD51 recombinase in double-strand break repair and meiotic recombination [ 6 ] . RAD52 binds ssDNA during recombination and also shows a quaternary organization similar to those of RecT/Redβ and ERF [ 16 26 ] . However, RAD52-like proteins showed no detectable sequence similarity with either the ERF or the RecT/Redβ-like proteins.
The clustering of functionally related genes in prokaryotic genomes into co-transcribed and co-regulated units, operons, often allows functional assignments through the principle of 'guilt by association' [ 30 31 32 ] . Generally, genes whose products physically interact to form a complex or are involved in successive steps in a biochemical pathway form operons that are conserved over large evolutionary distances [ 30 ] . On previous occasions, we have used gene neighborhoods or operons to predict novel DNA repair complexes and their components [ 33 ] . Accordingly, a similar approach was applied to the three families of SSAPs (RecT/Redβ, ERF, Rad52), to shed light on their functional links.
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