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Example sentences for: rect
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The clustering of functionally related genes in prokaryotic genomes into co-transcribed and co-regulated units, operons, often allows functional assignments through the principle of 'guilt by association' [ 30 31 32 ] . Generally, genes whose products physically interact to form a complex or are involved in successive steps in a biochemical pathway form operons that are conserved over large evolutionary distances [ 30 ] . On previous occasions, we have used gene neighborhoods or operons to predict novel DNA repair complexes and their components [ 33 ] . Accordingly, a similar approach was applied to the three families of SSAPs (RecT/Redβ, ERF, Rad52), to shed light on their functional links.
RecT and Redβ are evolutionarily related and define a widespread family of DNA recombination proteins
The sporadic distribution of the RecT and Redβ family proteins in bacterial genomes and their presence in phages suggest that these proteins ultimately are of phage origin and have been co-opted by the bacterial DNA recombination/repair systems.
We unify the Redβ and RecT proteins and their homologs, which have not been reported as being related at the sequence level, into a single superfamily, supporting the notion that these proteins share a similar mechanism of action.
Several lines of evidence, including genetic analyses, and similarities in biochemistry and quaternary structures, suggest that the E. coli RecT and phage λ Redβ proteins are functionally equivalent as mediators of single-strand exchange in DNA recombination [ 10 12 ] . However, no sequence similarity has been detected between these proteins leaving their actual evolutionary relationships unresolved.
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