Words similar to re-uptake
Example sentences for: re-uptake
How can you use “re-uptake” in a sentence? Here are some example sentences to help you improve your vocabulary:
The present data show that AVP-induced flank marking is selectively inhibited by chronic treatment with serotonin re-uptake inhibitors such as fluoxetine or clomipramine, instead of noradrenergic re-uptake inhibitors such as desipramine.
Selective serotonin re-uptake inhibitors are recognized as an effective biological treatment for OCD [ 20 ] . In a double blind, placebo control study, treating over 500 patients with OCD, clomipramine was found to be superior to placebo [ 30 ] . Differences between clomipramine and placebo were noted as early as one week after the start of treatment, with significant clinical improvement occurring after six weeks of treatment.
Fluoxetine also results in a significant reduction in OCD severity that takes several weeks to realize [ 31 32 ] . This therapeutic delay has been related to a down-regulation of serotonin autoreceptors with chronic exposure to elevated serotonin [ 33 34 ] . Together, these data have been used to link OCD with a dysfunction in serotonin neurotransmission [ 35 ] . Of course, it is unclear whether prolonged treatment with these re-uptake inhibitors is restricted to serotonin alone or impact on the activity of other neurotransmitter systems.
Clomipramine is a non-selective re-uptake inhibitor of serotonin, and to some extent norepinephrine [ 21 ] and fluoxetine is a selective serotonin re-uptake inhibitor [ 22 ] . Both of these drugs have proven to be effective in different animals models of OCD [ 23 ] . As an additional control, hamsters were also treated with desipramine, a noradrenergic re-uptake inhibitor [ 24 ] that has been found ineffective in inhibiting OCD in preclinical [ 25 ] and clinical studies [ 26 27 ] .
As noted earlier, fluoxetine is a selective serotonin re-uptake inhibitor while clomipramine is a non-selective re-uptake inhibitor of serotonin, and to some extent norepinephrine.
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