Words similar to rbx
Example sentences for: rbx
How can you use “rbx” in a sentence? Here are some example sentences to help you improve your vocabulary:
Biochemical studies identified SCF SKP2, an E3 that mediates p27 ubiquitylation in vitro [ 20 21 ] . This complex consists of at least four proteins: SKP1, CUL1, HRT1 (=RBX1/ROC1), and SKP2.
SCF complexes share homologues of the core components cullin 1 (CUL1), SKP1, and the RING domain protein HRT1/RBX1/ROC1, which associate with different F-box proteins and ubiquitin-conjugating enzymes [ 1].
In addition to the key roles in E3 ligase activity, RING finger domains have also been shown to be important for regulating subcellular localization of E3s and/or their substrates in a number of cases [ 53 54 55 56 ] . Studies have shown the MDM2 RING finger domain is required to promote nuclear export of p53 and this activity of MDM2 RING finger seems to be coupled with its ability to promote ubiquitination of p53 [ 53 54 55 ] . Rbx1/ROC1, the small RING finger subunit of the SCF E3 complexes, promotes the nuclear accumulation of Cul1, another subunit of the SCF complexes [ 56 ] . These studies have suggested a correlation between the ubiquitination activities of RING fingers and their roles in regulating subcellular localization of the E3 ligases which they are part of.
Based on the composition of known SCF complexes, we identified in the S. pombe genome database psh1 (pombe skp1 homologue) and pip1 (pop interacting protein 1), two genes encoding proteins with strong similarity to human SKP1 and HRT1/RBX1/ROC1, respectively (data not shown).
In line with this suggestion, it was previously demonstrated that HRT1/ROC1/RBX1 promotes nuclear accumulation of CUL1 [ 32 ] .
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