Words similar to rbx
Example sentences for: rbx
How can you use “rbx” in a sentence? Here are some example sentences to help you improve your vocabulary:
All human cullins interact with HRT1/RBX1/ROC1 [ 7], are modified by NEDD8 [ 8], and have ubiquitin ligase activity in vitro [ 9].
Biochemical studies identified SCF SKP2, an E3 that mediates p27 ubiquitylation in vitro [ 20 21 ] . This complex consists of at least four proteins: SKP1, CUL1, HRT1 (=RBX1/ROC1), and SKP2.
SCF complexes are E3s composed of the Cullin family member Cul1 (Cdc53 in S. cerevisiae ), as well as, Skp1, Roc1 (also called Rbx1 or Hrt1) and one of the numerous F-box proteins that act as a receptor for the substrate (for review see [ 2 ] ).
Based on the composition of known SCF complexes, we identified in the S. pombe genome database psh1 (pombe skp1 homologue) and pip1 (pop interacting protein 1), two genes encoding proteins with strong similarity to human SKP1 and HRT1/RBX1/ROC1, respectively (data not shown).
In line with this suggestion, it was previously demonstrated that HRT1/ROC1/RBX1 promotes nuclear accumulation of CUL1 [ 32 ] .
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