Words similar to rate-limiting
Example sentences for: rate-limiting
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In particular, high-density biochips including complementary deoxyribonucleic acid (cDNA) microarrays, oligonucleotide microarrays, and rapidly evolving proteomics platforms represent modern tools able to interrogate biology on a genome-wide scale and generate tens of thousands of data points simultaneously [ 1 ] . While researchers are beginning to appreciate the statistical rigors required for the analysis of genome-scale datasets, a rate-limiting step in knowledge growth occurs at the transition from statistical significance to biological discovery.
The transcript encoding ornithine decar-boxylase (ODC), a known androgen target that catalyzes the rate-limiting step in polyamine biosynthesis [ 26], was induced coordinately with enzymes that catalyze downstream steps in polyamine synthetic pathway (spermine synthase, spermidine/spermine N 1-acetyltransferase, and S-adenosylmethionine decarboxylase) (Figure 5c).
Overall, LC-PUFA may up regulate Pck1, the rate-limiting enzyme in gluconeogenesis, via cAMP-, SREBP-1- and/or PPAR-signaling [ 57 ] . This has the overall effect of limiting fat accumulation and shunting metabolic flux to gluconeogenesis.
For instance, MMTV-Cdc37 transgenic mice develop mammary gland tumors at a rate comparable to that observed previously in MMTV-cyclin D1 mice, indicating that Cdc37 can function as an oncogene in mice and suggests that the establishment of protein kinase pathways mediated by Cdc37-Hsp90 can be a rate-limiting event in transformation [ 76 ] . Also, analysis of proteins that co-immunoprecipitated with Cdk6 and Cdk4 has shown complexes containing both Hsp90 and Cdc37 [ 77 78 79 ] .
In this work, the levels of Tag in G 1 increased 18% during exponential population growth as the length of G 1 was increasing [ 11 ] . Since Tag is rate-limiting for G 1 transit in these cells, the increase in transit time as a function of G 1 Tag concentration represented an apparent paradox that is resolved (in the simplest and obvious manner) by stating that additional rate-limiting entities operate to set the G 1 transit time.
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