Example sentences for: rate-limiting

How can you use “rate-limiting” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Since Tag did not decrease simultaneously with an increasing G 1 time, and since Tag was one of the G 1 rate-limiting molecules, the activity of Tag must have been decreasing while Tag levels increased.

  • For instance, MMTV-Cdc37 transgenic mice develop mammary gland tumors at a rate comparable to that observed previously in MMTV-cyclin D1 mice, indicating that Cdc37 can function as an oncogene in mice and suggests that the establishment of protein kinase pathways mediated by Cdc37-Hsp90 can be a rate-limiting event in transformation [ 76 ] . Also, analysis of proteins that co-immunoprecipitated with Cdk6 and Cdk4 has shown complexes containing both Hsp90 and Cdc37 [ 77 78 79 ] .

  • Ablation of HIF-1α in skeletal muscle was associated with an increase in the activity of rate-limiting enzymes of the mitochondria, indicating that the citric acid cycle and increased fatty acid oxidation may be compensating for decreased flow through the glycolytic pathway in these animals.

  • Overall, the rate-limiting production steps following the reaction optimization were those involving the analysis of the products.

  • Since the level of SKP2 is a rate-limiting determinant of p27 levels [ 20 21 29 ] , we examined the effect of MIB on SKP2 protein levels.


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