Words similar to rate-limiting
Example sentences for: rate-limiting
How can you use “rate-limiting” in a sentence? Here are some example sentences to help you improve your vocabulary:
It has been argued [ 7 ] that the cytosolic vitamin D-dependent calcium binding protein calbindin D 9K is the likely rate-limiting step in vitamin D-induced intestinal calcium absorption.
For instance, MMTV-Cdc37 transgenic mice develop mammary gland tumors at a rate comparable to that observed previously in MMTV-cyclin D1 mice, indicating that Cdc37 can function as an oncogene in mice and suggests that the establishment of protein kinase pathways mediated by Cdc37-Hsp90 can be a rate-limiting event in transformation [ 76 ] . Also, analysis of proteins that co-immunoprecipitated with Cdk6 and Cdk4 has shown complexes containing both Hsp90 and Cdc37 [ 77 78 79 ] .
Phosphoenolpyruvate carboxykinase (Pck1) is the rate-limiting enzyme of gluconeogenesis, and most of its activity is regulated transcriptionally.
The 26S proteasome is responsible for the bulk turnover of cytoplasmic and nuclear proteins in eukaryotic cells and also plays a key role in the regulation of cell cycle, signal transduction, transcription as well as antigen presentation [ 17 18 19 20 21 ] . Most of the known proteasomal substrates are marked and targeted to proteasome by ubiquitination [ 17 19 20 ] . Ubiquitination, however, is not an obligatory step for substrate targeting to proteasome [ 17 18 20 ] . The degradation of the ornithine decarboxylase (ODC), the rate-limiting enzyme for polyamine synthesis, involves a protein named antizyme (Az), which binds and targets ODC to 26S proteasome for degradation [ 18 ] . However, ODC has remained an "orphan" in Az-dependent proteasomal degradation.
In particular, high-density biochips including complementary deoxyribonucleic acid (cDNA) microarrays, oligonucleotide microarrays, and rapidly evolving proteomics platforms represent modern tools able to interrogate biology on a genome-wide scale and generate tens of thousands of data points simultaneously [ 1 ] . While researchers are beginning to appreciate the statistical rigors required for the analysis of genome-scale datasets, a rate-limiting step in knowledge growth occurs at the transition from statistical significance to biological discovery.
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