Words similar to raloxifene

Example sentences for: raloxifene

How can you use “raloxifene” in a sentence? Here are some example sentences to help you improve your vocabulary:

Another SERM, raloxifene, also shows promise [ 29].
Raloxifene was a gift from Stefan Nilsson (KaroBio AB, Huddinge, Sweden).
ERα enhances AP-1 activity in response to estrogens, [ 28 29 ] but ERβ inhibits AP-1 activity in response to estrogens [ 29 30 31 ] . ERβ also completely suppresses ERα activity at the cyclin D1 promoter and even suppresses the activity of an ERα mutant that is selectively superactive at AP-1 sites and CREs [ 29 ] . Finally, ERβ shows a unique capacity to enhance AP-1 activity in response to selective estrogen receptor modulators (SERMs) such as raloxifene, tamoxifen and ICI 182,780/Faslodex (ICI) [ 30 31 32 ] . Together, these observations suggest that there are fundamental differences in the way that the ERs bind unspecified cofactors that modulate gene expression, and that some of these cofactors must play a role in differential ER activity at AP-1 sites.
Moreover, these interactions were suppressed by SERMs (ICI, raloxifene and tamoxifen).
Unlike anti-estrogens, such as tamoxifen or raloxifene, ligands targeted against the RAR isoforms can present anticancer activity against both estrogen receptor positive and negative breast tumor cells [ 1].