Words similar to quasispecies

Example sentences for: quasispecies

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RNA viruses form highly polymorphic clouds of mutants, so-called quasispecies [ 1 2 3 ] . At viral loads of 10 8or more virions in an infected host, viral quasispecies in vivo often contain all possible single-point mutants from the consensus sequence, as well as a sizeable fraction of two- or three-point mutants [ 4 ] . Besides their importance as pathogens, RNA viruses have in recent years also become one of the main tools for experimental verification of theoretical population genetics and evolutionary theory in general (reviewed in [ 3 ] ). This line of research can draw on a substantial body of literature on the theory of quasispecies dynamics and its relation to standard population genetics [ 5 6 7 8 9 10 11 12 13 14 15 16 ] .
We have developed an algorithm for using sequence data to map the positively selected mutations of viral quasispecies.
, the fraction of mutant present in mutation-selection balance should be larger (up to a factor of two) than predicted by the standard quasispecies model if the mutant fitness is low compared to the wild-type fitness.
Also, we may use selection mapping to analyze HIV breakthrough infections to determine if vaccines prevented the HIV quasispecies from inhabiting normally advantageous regions of the quasispecies sequence space.
noted that mutant concentrations around 10 -3would follow from equilibrium state of the standard quasispecies model if the mutation rate were μ = 10 -3rather than μ = 10 -4.